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Keratosis palmoplantaris with esophageal cancer

Also Known As:

Howell Evans syndrome; Keratosis Palmaris Et Plantaris With Esophageal Cancer; Tylosis with esophageal cancer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Site: 4
  - Head and Neck Neoplasms: 18117
    - Esophageal Neoplasms: 14579
      - Keratosis palmoplantaris with esophageal cancer: 2
  - Digestive System Neoplasms: 236
    - Gastrointestinal Neoplasms: 4373
      - Esophageal Neoplasms: 14579
        Keratosis palmoplantaris with esophageal cancer: 2
Digestive System Diseases: 1042
- Gastrointestinal Diseases: 5874
  - Gastrointestinal Neoplasms: 4373
    - Esophageal Neoplasms: 14579
      - Keratosis palmoplantaris with esophageal cancer: 2
  - Esophageal Diseases: 379
    - Esophageal Neoplasms: 14579
      - Keratosis palmoplantaris with esophageal cancer: 2
- Digestive System Neoplasms: 236
  - Gastrointestinal Neoplasms: 4373
    - Esophageal Neoplasms: 14579
      - Keratosis palmoplantaris with esophageal cancer: 2
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Genetic Skin Diseases: 47
    - Palmoplantar Keratoderma: 313
      - Keratosis palmoplantaris with esophageal cancer: 2
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Keratosis: 706
    - Palmoplantar Keratoderma: 313
      - Keratosis palmoplantaris with esophageal cancer: 2
  - Genetic Skin Diseases: 47
    - Palmoplantar Keratoderma: 313
      - Keratosis palmoplantaris with esophageal cancer: 2

Related Diseases

1.	Esophageal Neoplasms (Esophageal Cancer)

Experts

1.	Blaydon, Diana C: 1 article (01/2021)
2.	Chao-Chu, Jennifer: 1 article (01/2021)
3.	Kelsell, David P: 1 article (01/2021)
4.	Murtough, Stephen: 1 article (01/2021)
5.	Pennington, Daniel J: 1 article (01/2021)
6.	Zaman, Najwa: 1 article (01/2021)
7.	Burzenski, Lisa M: 1 article (01/2018)
8.	Farley, Michelle L: 1 article (01/2018)
9.	Hosur, Vishnu: 1 article (01/2018)
10.	Low, Benjamin E: 1 article (01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Keratosis palmoplantaris with esophageal cancer:

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/2018 - "RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?"
2.	Proteins (Proteins, Gene)FDA Link 01/01/2021 - "The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. "