Keratomalacia

12/01/1975 - "A retrospective review of 3,490 adminissions to the major pediatric facility in El Salvador was undertaken to determine whether biannual administration of massive doses of vitamin A (200,000 international units) to all availabel 1- to 4-year-old children was effective in preventing keratomalacia. "
01/01/2022 - "The finding of significantly increased cord blood retinol levels when compared to maternal retinol levels in the present study suggests that some compensatory mechanisms, such as increased placental RBP levels, support the presentation of retinol to the fetus, even if the mother has a retinol deficiency."
08/01/2004 - "Numerous studies demonstrate that vitamin A (retinol) deficiency causes abnormal cardiovascular morphogenesis. "
01/01/2022 - "Umbilical cord blood retinol deficiency was more common in the male participants, while the transplacental retinol passage rate was higher in females. "
01/01/2022 - "Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency."

05/01/2018 - "CONCLUSIONS AND CLINICAL RELEVANCE Results suggested EDTA, tetracyclines, and NAC may be beneficial for topical treatment of keratomalacia, but in vivo studies are required."

05/01/2018 - "CONCLUSIONS AND CLINICAL RELEVANCE Results suggested EDTA, tetracyclines, and NAC may be beneficial for topical treatment of keratomalacia, but in vivo studies are required."

07/01/1948 - "A CASE OF KERATOMALACIA CURED BY PENICILLIN AND VITAMIN A."

01/01/2016 - "To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet(®) Corneal Discs) in equid patients with keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. "

01/17/2020 - "Correction: An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency."
02/13/2015 - "An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency."
09/01/2006 - "Retinylester (RE) pools serve as a source of retinol for retinoic acid production under retinol deficiency and when required for proper differentiation. "
01/30/2001 - "Thus, Adh1 plays a major role in the metabolism of a large dose of retinol to retinoic acid in adults, whereas Adh4 plays a role in maintaining sufficient retinol metabolism for development during retinol deficiency. "
02/01/1996 - "In conclusion, retinol deficiency reduces diabetes and insulitis in DP BB/Wor rats, and retinoic acid can at least partly substitute for retinol in the development of insulitis."

02/25/1988 - "Thus, as in the liver, in the visceral yolk sac retinol deficiency inhibits RBP secretion without altering RBP mRNA levels. "
11/01/1997 - "Hyperoxia alone reduced pro alpha 1 (I) mRNA by 60 +/- 4% (p < .05) and pro alpha 1 (III) mRNA by 30 +/- 5% (p < .05), and retinol deficiency alone reduced pro alpha 1 (I) mRNA abundance by 49 +/- 8.8% (p < .05) and pro alpha 1 (III) mRNA abundance by 14 +/- 7.5% (p = not significant), respectively. "
03/01/1992 - "Retinol deficiency caused an almost 50% decrease in isoform beta mRNA levels of adipose tissue, whereas little change occurred in the abundance of alpha and gamma isoforms transcripts in this tissue. "
09/15/1991 - "Retinol deficiency caused a 65-70% decrease in the mRNA levels of lung and liver RAR-beta, whereas no change was observed in RAR-alpha and -gamma mRNA levels in these organs. "
10/31/1988 - "Retinol deficiency resulted in decreased mRNA levels for cellular retinol-binding protein (CRBP) in the lungs and the testes. "

02/01/1986 - "It is assumed that retinol deficiency causes of weakening of hydrophobic interactions within the membrane as well as partial translocation of the enzymes from the hydrophobic to the hydrophilic layer."
02/01/1986 - "[Effect of retinol deficiency on the activity and solubility of various enzymes of the endoplasmic reticulum membranes in the rat liver]."
05/01/1991 - "[Keratomalacia in rheumatoid arthritis: immunohistologic and enzyme histochemical studies]."
12/01/1988 - "In the liver, initial retinol deficiency did not sensitively modify ODC activity, and retinoic acid then stimulated the enzyme abnormally. "
01/01/1978 - "Starting from the fact that extensive retinol deficiency leads to morphological pancreatic alterations, the secretion of the gland and the specific enzyme activities in the pancreatic tissue were studied in rats fed a retinol-free diet for 70 days. "

06/01/2010 - "A higher prevalence of retinol deficiency (60% versus 26.7%, P = 0.009) and beta-carotene deficiency (23.3% versus 3.3%, P = 0.026) was found in the group with human immunodeficiency virus than in the control group. "
11/01/2009 - "Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats."
11/01/2009 - "This study aimed at comparing antioxidant potential of fucoxanthin (FUCO) with beta-carotene in relieving lipid peroxidation (Lpx) caused by retinol deficiency (RD) in rats. "

10/01/2016 - "Animal models of vitamin A (retinol) deficiency have highlighted its crucial role in reproduction and placentation, whereas an excess of retinoids (structurally or functionally related entities) can cause toxic and teratogenic effects in the embryo and foetus, especially in the first trimester of human pregnancy. "
03/01/1992 - "In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in rat adipose tissue. "

05/01/2003 - "Corneal grafting surgery in keratomalacia is associated with poor visual outcome."
05/01/2003 - "Keratoplasty for keratomalacia in preschool children."
06/01/2007 - "Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced by uncontrolled phenylketonuria."
01/01/2016 - "To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet(®) Corneal Discs) in equid patients with keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. "

04/01/2020 - "To evaluate the clinical and visual outcomes following intensive medical therapy for keratomalacia in dogs. "
04/01/2020 - "Outcome of medical therapy for keratomalacia in dogs."
09/06/1951 - "[Keratomalacia therapy]."
04/01/2020 - "Intensive medical therapy has the potential to achieve healing of some ulcers with keratomalacia. "
01/01/2013 - "If keratomalacia (melting) is observed, anticollagenase/antiprotease therapy, such as autologous serum, is indicated. "

09/01/1973 - "Therapeutic penetrating keratoplasty in keratomalacia."
06/01/2007 - "To report a patient with a rare complication of bilateral keratomalacia induced by uncontrolled phenylketonuria (PKU) that was successfully treated with amniotic membrane transplantation in 1 eye and penetrating keratoplasty in the second eye. "
01/01/2000 - "During the first week early problems in suturing penetrating keratoplasty in five patients were associated with the instability of the recipients' corneal stroma (stromal thinning in keratoconus or corneal herpes, suture problems in keratomalacia, active herpes keratitis, corneal burns, or rheumatic diseases). "

09/01/2005 - "Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses."
06/01/2007 - "To report a patient with a rare complication of bilateral keratomalacia induced by uncontrolled phenylketonuria (PKU) that was successfully treated with amniotic membrane transplantation in 1 eye and penetrating keratoplasty in the second eye. "

03/21/2023 - "The short-term complications were suture dehiscence (two of 12) and progression of the keratomalacia (one of 12). "
01/01/2000 - "During the first week early problems in suturing penetrating keratoplasty in five patients were associated with the instability of the recipients' corneal stroma (stromal thinning in keratoconus or corneal herpes, suture problems in keratomalacia, active herpes keratitis, corneal burns, or rheumatic diseases). "