Binder type Maxillonasal dysplasia

Maxillofacial abnormalities characterized by a short nose with a flat bridge, a short columella, an acute nasolabial angle, perialar flatness, a convex upper lip, and a tendency to an ANGLE CLASS III MALOCCLUSION. Critical features of the syndrome appear to be midfacial hypoplasia, lack of anterior nasal spine, and malocclusion. May be hereditary (autosomal recessive) or multifactorial. OMIM: 155050

Also Known As:

Networked: 15 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lithiasis
2.	Vitamin K Deficiency
3.	Deafness (Deaf Mutism)
4.	Cleft Lip (Harelip)
5.	Chondrodysplasia Punctata (Stippled Epiphyses)

Experts

1.	Fan, Fei: 2 articles (09/2017 - 11/2016)
2.	Lu, Xiaona: 2 articles (09/2017 - 11/2016)
3.	Tian, Le: 2 articles (09/2017 - 11/2016)
4.	Wang, Huan: 2 articles (09/2017 - 11/2016)
5.	You, Jianjun: 2 articles (09/2017 - 11/2016)
6.	Zhang, Bo: 2 articles (09/2017 - 11/2016)
7.	Barbera, Giorgio: 1 article (01/2021)
8.	Della Monaca, Marco: 1 article (01/2021)
9.	Nocini, Riccardo: 1 article (01/2021)
10.	Priore, Paolo: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Binder type Maxillonasal dysplasia:

1.	Cytidine Diphosphate (CDP)IBA 07/01/2012 - "This study reviewed the management and outcome of patients with Binder syndrome and CDP in a multidisciplinary setting. " 07/01/2012 - "Because of the phenotypic characteristics shared by both Binder syndrome and CDP, it is most likely that Binder syndrome is not a syndrome, nor is it an entity, but most likely to be an "association." We would advocate that these patients should be managed in a multidisciplinary setting." 07/01/2012 - "Seventy-seven patients were treated over the 30-year period (5 patients were lost to follow-up); of the remaining 72 patients, 60 (83%) had Binder syndrome, and 12 (17%) were patients with CDP. " 07/01/2012 - "Patients with chondrodysplasia punctata (CDP) usually present with Binder-type features, and often CDP is misdiagnosed as Binder syndrome. "
2.	SiliconesIBA 09/01/2017 - "A retrospective study of 25 Binder syndrome patients (9 with silicone and 16 with costal cartilage) was managed. " 09/01/2017 - "In this article, the authors reported surgical details and experience of nasal framework reconstruction of Binder syndrome, compare the esthetic outcomes of 2 grafts: autologous costal cartilage and L-shaped silicone covered with auricular cartilage. " 09/01/2017 - "Comparison of Two Different Grafts in Nasal Framework Reconstruction of Binder Syndrome: Cartilage and Silicone." 11/01/2016 - "[Comparison of costochondral nasal framework reconstruction and silicone graft implantation in improving the midface depression of Binder syndrome]." 03/01/2010 - "Early tissue expansion with the placement of alloplastic silicone implants effectively stretches the constricted nasal soft tissues in Binder syndrome to limit graft resorption after definitive nasal reconstruction with costochondral rib grafts. "
3.	Vitamin KFDA Link 03/01/2005 - "This observation should prompt physicians to carefully check for vitamin K deficiency in pregnant women presenting with biliary lithiasis, in order to prevent Binder syndrome in the fetus by providing intravenous vitamin K supplementation as soon as possible. "
4.	Growth Hormone (Somatotropin)IBA 05/01/1990 - "A 15 years old boy was deferred to our department with growth hormone deficiency, deafness with middle ear bones involvement, and a facial dysmorphy called Binder syndrome. "
5.	SolutionsIBA 07/01/2008 - "Case report and surgical solution for nasal spine agenesis in a woman with Binder syndrome."
6.	SiliconIBA 11/01/2016 - "To compare the clinical effects of costal cartilage grafts and silicon with auricular cartilage in correcting the midfacial depression of Binder syndrome. "
7.	Phenytoin (Dilantin)FDA LinkGeneric 09/11/1995 - "Ten patients with maxillonasal hypoplasia (Binder "syndrome"), who were prenatally exposed to phenytoin (usually in combination with other anticonvulsants), were identified retrospectively. "
8.	Anticonvulsants (Antiepileptic Drugs)IBA 09/11/1995 - "Ten patients with maxillonasal hypoplasia (Binder "syndrome"), who were prenatally exposed to phenytoin (usually in combination with other anticonvulsants), were identified retrospectively. "

Therapies and Procedures

1.	Transplantation 05/01/2014 - "Single rib-cartilage recombination transplantation in Binder syndrome treatment has lots of advantages, such as less morbidity, rapid recovery, and good results." 05/01/2014 - "To explore the surgical methods and advantages of single rib-cartilage recombination transplantation in Binder syndrome treatment. " 05/01/2014 - "[Primary report of single rib-cartilage recombination transplantation in Binder syndrome treatment]."
2.	Osteotomy 04/01/1997 - "The present study prospectively assesses the skeletal stability in a consecutive series of Binder syndrome patients (n = 7), aged 16 to 20 years, who underwent LeFort I osteotomy fixed with miniplates and the associated morbidity. " 01/01/2013 - "Modified nasomaxillary and hard palatine osteotomy combined nasal implantation to correct Binder syndrome." 04/01/1997 - "Binder syndrome: staging of reconstruction and skeletal stability and relapse patterns after LeFort I osteotomy using miniplate fixation." 09/01/2022 - "A Periodic Case of Maxillo-Nasal Dysplasia or Binder Syndrome Successfully Operated With Bilateral Le Fort II Osteotomy With Distraction Osteogenesis." 01/01/2013 - "As the result showed modified nasomaxillary complex and hard palatine "box" osteotomy can be a good alternative for advancement of midfacial hypoplasia instead of traditional Le Fort I, II osteotomy, chondrocostal bone graft is a perfect option to correct nasal deformity of Binder syndrome, and both can satisfy requirement of patients."
3.	Rhinoplasty 01/01/2021 - "In the present work, the authors describe, step by step, their technique in secondary rhinoplasty in a 36-years-old patient affected by Binder Syndrome. " 01/01/2021 - "Secondary Rhinoplasty in Binder Syndrome: Considerations and Management of Complex Problem With Heterologous Bone Graft." 03/01/2016 - "Since 2013, 3 female patients; 2 of them with Binder syndrome and 1 cleft lip/palate patient (average 18 years) with previous rhinoplasty (3-6 procedures) are subjected to secondary rhinoplasty using GPFF turning it over the osteochondral nasal framework. "
4.	Orthognathic Surgery 04/01/1997 - "In our series, a staged reconstructive approach for Binder syndrome was carried out in the teenage years and included orthodontic treatment, orthognathic surgery, and nasal augmentation. "
5.	Distraction Osteogenesis 09/01/2022 - "A Periodic Case of Maxillo-Nasal Dysplasia or Binder Syndrome Successfully Operated With Bilateral Le Fort II Osteotomy With Distraction Osteogenesis."