Congenital anosmia

An autosomal dominat congenital form of anosmia that has been mapped to chromosome 18. OMIM: 107200

Also Known As:

Anosmia, Congenital; Anosmia, Isolated Congenital; Isolated congenital anosmia

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Sensation Disorders: 117
    - Olfaction Disorders: 357
      - Congenital anosmia: 7
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Sensation Disorders: 117
      - Olfaction Disorders: 357
        Congenital anosmia: 7

Related Diseases

1.	Synkinesis
2.	Kallmann Syndrome (Kallmann's Syndrome)
3.	Atrophic Rhinitis (Ozena)
4.	Hypogonadism (Hypergonadotropic Hypogonadism)
5.	Diverticulum

Experts

1.	Braun, J J: 1 article (03/2020)
2.	Migueres, N: 1 article (03/2020)
3.	de Blay, F: 1 article (03/2020)
4.	Almpani, Konstantinia: 1 article (01/2020)
5.	Arora, Gazal: 1 article (01/2020)
6.	Balasubramanian, Ravikumar: 1 article (01/2020)
7.	Buitrago, Tatiana Pineda: 1 article (01/2020)
8.	Capri, Yline: 1 article (01/2020)
9.	Chalmers, Laura: 1 article (01/2020)
10.	Cho, Chie-Hee: 1 article (01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital anosmia:

1.	Testosterone (Sustanon)FDA Link 11/01/2015 - "Examination confirmed clinical features of Kallmann syndrome including unilateral cryptorchidism, micropenis, congenital anosmia, and bimanual synkinesis (mirror movements), with reduced serum testosterone and normal gonadotropin levels demonstrating hypogonadotropic hypogonadism. "
2.	Phenylethyl Alcohol (Phenethyl Alcohol)IBA 08/01/1998 - "Olfactory function was evaluated by OEP and standardized psychophysical measures including smell identification test and odor detection threshold tests for 3 chemosensory stimulants: phenylethyl alcohol (PEA), isoamyl acetate (IAA), and chloracetyl phenone (CAP) in 9 subjects with isolated congenital anosmia and 9 age- and gender-matched normosmic controls. "
3.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/01/2020 - "The observation that congenital anosmia (inability to smell) is often associated with GnRH deficiency in humans led to the prevailing view that GnRH neurons depend on olfactory structures to reach the brain, but this hypothesis has not been confirmed. "
4.	Indicators and Reagents (Reagents)IBA 11/01/2011 - "The depth of the olfactory sulcus is an indicator of congenital anosmia."
5.	Immunoglobulin G (IgG)IBA 03/01/2020 - "The laboratory work-up essentially revealed IgG4 deficiency and imaging demonstrated bronchiectasis (lingula), multiple tracheobronchial diverticula, atrophic rhinitis and congenital anosmia with agenesis of the olfactory bulbs and sulci. "
6.	GonadotropinsIBA 11/01/2015 - "Examination confirmed clinical features of Kallmann syndrome including unilateral cryptorchidism, micropenis, congenital anosmia, and bimanual synkinesis (mirror movements), with reduced serum testosterone and normal gonadotropin levels demonstrating hypogonadotropic hypogonadism. "
7.	Coffee FDA Link 04/01/1998 - "Children who can't smell the coffee: isolated congenital anosmia."
8.	isoamyl acetateIBA 08/01/1998 - "[Olfactory event-related potentials to isoamyl acetate in congenital anosmia]." 08/01/1998 - "Olfactory function was evaluated by OEP and standardized psychophysical measures including smell identification test and odor detection threshold tests for 3 chemosensory stimulants: phenylethyl alcohol (PEA), isoamyl acetate (IAA), and chloracetyl phenone (CAP) in 9 subjects with isolated congenital anosmia and 9 age- and gender-matched normosmic controls. "
9.	amyl acetate (pentyl acetate)IBA 04/01/1997 - "In the subjects with congenital anosmia, no reproducible evoked potential components were identified in response to amyl acetate. " 04/01/1997 - "Olfactory event-related potentials to amyl acetate in congenital anosmia."