Neurosarcoidosis

01/01/2020 - "Infliximab is an effective treatment in neurosarcoidosis leading to remission or improvement in 70%. "
01/01/2016 - "Intractable Neurosarcoidosis Effectively Treated with Infliximab."
07/01/2010 - "We report a patient with refractory neurosarcoidosis who showed dramatic improvement in the clinical and radiological manifestations following treatment with infliximab; he suffered a relapse upon discontinuation of the medication."
10/01/2007 - "Dramatic MRI improvement with refractory neurosarcoidosis treated with infliximab."
01/01/2020 - "This study provides Class IV evidence that in people with pathology-confirmed neurosarcoidosis, infliximab is beneficial."

01/01/2022 - "The patient was definitively diagnosed with neurosarcoidosis (NS) and his condition improved with high dose corticosteroids and additional immunosuppressive therapies. "
08/01/2013 - "Corticosteroids are the mainstay of treatment for neurosarcoidosis. "
12/01/2007 - "Corticosteroids have been the mainstay of treatment of neurosarcoidosis with success at halting progression of the immune process in 50% cases. "
08/01/2003 - "Corticosteroids remain the mainstay of treatment of neurosarcoidosis."
05/01/2014 - "TREATMENT OF NEUROSARCOIDOSIS: Although a lot of drugs have proved useful in treating neurosarcoidosis, corticosteroids are still the gold standard in treatment of these patients. "

01/01/2020 - "Based on the clinical picture, the diagnosis of neurosarcoidosis was made, and high-dose steroids were started and resulted in significant improvement."
12/13/2016 - "This study provides Class IV evidence that for patients with neurosarcoidosis taking steroids, MTX is superior to MMF in reducing the risk of relapse."
01/01/1990 - "A final diagnosis of neurosarcoidosis was made and the patient responded well to oral steroids."
05/01/2022 - "However, evidence regarding the treatment of steroid-refractory neurosarcoidosis is scarce, and treatment strategies for such patients have not been established. "
01/01/2021 - "One patient was lost to follow up prior to steroid taper, and another was withdrawn due to worsening of known neurosarcoidosis. "

02/01/2013 - "Neurosarcoidosis in a patient treated with tumor necrosis factor alpha inhibitors."
12/01/2022 - "In recent years, however, studies have demonstrated the effectiveness of anti-tumor necrosis factor (anti-TNF) therapy in the treatment of neurosarcoidosis, leading to improved outcomes. "
01/01/2018 - "Extrapyramidal signs in neurosarcoidosis versus multiple sclerosis: Is TNF alpha the link?"
12/01/2006 - "Optic neuropathy in refractory neurosarcoidosis treated with TNF-alpha antagonist."
08/01/2013 - "Tumor necrosis factor-alpha inhibitors, including infliximab, are effective for refractory neurosarcoidosis. "

01/01/2010 - "Studies have shown that the optimal diagnostic imaging modality for neurosarcoidosis is magnetic resonance imaging with gadolinium as it enhances visualization of granulomatous infiltration in neural tissue. "
05/01/2022 - "The brain MRI also revealed thickening and gadolinium enhancement of hypothalamus/optic chiasm which is also a common site of involvement in neurosarcoidosis. "
09/01/2016 - "While the imaging modality of choice to diagnose neurosarcoidosis is gadolinium-enhanced MRI, F-FDG PET/CT maybe used to stage the disease or target the optimal biopsy site. "
12/15/2013 - "Neurosarcoidosis: correlation of cerebrospinal fluid findings with diffuse leptomeningeal gadolinium enhancement on MRI and clinical disease activity."
08/01/2013 - "Gadolinium-enhanced magnetic resonance imaging (MRI) of the brain and spinal cord is the most sensitive test for neurosarcoidosis, while the diagnostic specificity of cerebrospinal fluid (CSF) analysis is limited. "

10/01/1992 - "The treatment of neurosarcoidosis with cyclosporine."
10/01/1992 - "Six patients with refractory neurosarcoidosis were enrolled in a 12-month open-label trial to investigate the safety and efficacy of cyclosporine therapy. "
07/01/2002 - "Therapy with corticosteroid and immunosuppressive drugs, such as cyclosporine A, and other treatment approaches to neurosarcoidosis are also accounted for."
10/01/1992 - "Cyclosporine treatment is a reasonably safe and effective adjunct to corticosteroid therapy for patients with refractory neurosarcoidosis, although clinical deterioration can occur despite combination therapy."
04/01/2007 - "Neurosarcoidosis is usually treated with corticosteroid therapy and immunosuppressive drugs (cyclophosphamide, cyclosporine, aziathoprine, methotrexate), but frequently resists standard schedules. "

01/01/2011 - "Isolated spinal cord neurosarcoidosis diagnosed by cord biopsy and thalidomide trial."
01/28/2008 - "Our case report presents a difficult, refractory case of neurosarcoidosis that demonstrates an altered prognosis based on the addition of thalidomide."
01/28/2008 - "Prognosis of refractory neurosarcoidosis altered by thalidomide: a case report."
12/01/2007 - "Thalidomide for acute treatment of neurosarcoidosis."
01/28/2008 - "Thalidomide has been shown to have activity specific to the inflammatory mediators of sarcoidosis, has been shown to be beneficial in cutaneous sarcoidosis, and provides an interesting observation in our patient with refractory neurosarcoidosis. "

12/01/2014 - "Based on exclusion of alternative etiologies, a diagnosis of neurosarcoidosis was made and the patient was started on methotrexate for 9 months, with minimal improvement. "
02/01/1990 - "Neurosarcoidosis: therapeutic success with methotrexate."
12/13/2016 - "To compare the efficacy of methotrexate (MTX) and mycophenolate mofetil (MMF) in the prevention of relapses in neurosarcoidosis. "
12/13/2016 - "Treatment of neurosarcoidosis: A comparative study of methotrexate and mycophenolate mofetil."
08/01/2015 - "Neurosarcoidosis was suspected and treatment with glucocorticoids and methotrexate initiated. "

01/01/2017 - "Neurosarcoidosis manifestations generally responded well to high-dose glucocorticoids in the majority of patients, but relapse was common."
05/01/2023 - "Our case demonstrates the diagnostic difficulty of neurosarcoidosis while displaying the importance of early initiation of glucocorticoids in the acute inpatient setting."
05/01/2023 - "Resolution of Possible Neurosarcoidosis With Early Initiation of Glucocorticoids in the Acute Inpatient Setting: A Case Report."
11/01/2017 - "Moderate to high dose of glucocorticoids is the main therapy for neurosarcoidosis. "
05/01/2007 - "Neurosarcoidosis often responds to glucocorticoids, usually within days or weeks of initiating therapy. "

01/01/2018 - "Successful therapy with rituximab in three patients with probable neurosarcoidosis."
12/01/2022 - "Neurosarcoidosis during the treatment of primary Sjögren's syndrome: is it a paradoxical effect of rituximab?"
01/01/2019 - "Novel Use of Rituximab in Treatment of Refractory Neurosarcoidosis in an 11-Year-Old Girl."
01/01/2018 - "Rituximab may be used for patients with neurosarcoidosis who are nonresponsive to established treatment regimes."
08/10/2010 - "A case of neurosarcoidosis successfully treated with rituximab."

12/01/2022 - "There is an unmet need for randomized controlled trials that provide robust data to guide therapy and the long-term management of neurosarcoidosis patients."
08/01/1989 - "There have been no controlled studies of therapy in neurosarcoidosis. "
01/01/2022 - "Neurosarcoidosis: an update on diagnosis and therapy."
03/27/2018 - "[Neurosarcoidosis - diagnosis, clinical picture and therapy]."
01/01/2018 - "This report highlights a case of probable neurosarcoidosis nearly a year after discontinuation of immune checkpoint therapy. "

03/01/2008 - "Remission of refractory neurosarcoidosis treated with brain radiotherapy: a case report and a literature review."
12/01/2008 - "The purpose of this case report was to illustrate and discuss the diagnostic and therapeutic challenges faced in the management of neurosarcoidosis, as well as document our experience with the use of stereotactic radiotherapy in the treatment of neurosarcoidosis."
12/01/2008 - "We report the case of a 38-year-old, female patient with neurosarcoidosis involving the pituitary gland and hypothalamus, who was treated with stereotactic radiotherapy (24 Gy in 12 fractions) with an excellent result. "
12/01/2008 - "Stereotactic radiotherapy for the treatment of neurosarcoidosis involving the pituitary gland and hypothalamus."
09/01/2004 - "Neurosarcoidosis: an unusual indication for radiotherapy."

01/01/2020 - "This prospective study of the natural history and treatment response in neurosarcoidosis provides evidence that the use of high dose immunosuppression and early and prolonged use of biological therapies is associated with greatly improved outcomes and lower mortality. "

12/01/1998 - "Under oral administration of steroids, all three cases recovered with complete remission of neurosarcoidosis except for endocrinological symptoms. "

08/01/1998 - "Iatrogenic breast mass associated with a malfunctioning ventriculoperitoneal shunt in a patient with neurosarcoidosis."
03/01/1989 - "Six patients were diagnosed with neurosarcoidosis and had electrophoresis of serum and cerebrospinal fluid performed (one patient with a ventriculoperitoneal shunt was later excluded). "
01/01/2022 - "Teaching Video NeuroImage: Parinaud Syndrome Due to Ventriculoperitoneal Shunt Malfunction in a Patient With Neurosarcoidosis."
03/01/2021 - "We present a patient who developed acute hydrocephalus due to neurosarcoidosis, for which he had to be operated on; soon after the operation, cranial infection developed that required definitive drainage system and ventriculoperitoneal shunt had to be implanted. "