Dyschromatosis universalis hereditaria

A rare herditary skin condition characterized by hyper- and hypopigmented macules of variable size and shape that appear in infancy or early childhood on the trunk, limbs, and sometimes the face. There may also be abnormalities affecting the hair, nails, and dermal connective tissue as well as nerves. OMIM: 127500

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Lentigo (Lentiginosis)
2.	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita)
3.	Hyperpigmentation
4.	Dowling-Degos Disease
5.	Naegeli syndrome

Experts

1.	Dai, Hongying: 2 articles (10/2017 - 01/2017)
2.	He, Lin: 2 articles (10/2017 - 01/2017)
3.	He, Yong: 2 articles (10/2017 - 01/2017)
4.	Kuang, Zhongshu: 2 articles (10/2017 - 01/2017)
5.	Liu, Beizhong: 2 articles (10/2017 - 01/2017)
6.	Luo, Huangchao: 2 articles (10/2017 - 01/2017)
7.	Ma, Jiangshu: 2 articles (10/2017 - 01/2017)
8.	Wang, Ke: 2 articles (10/2017 - 01/2017)
9.	Xing, Qinghe: 2 articles (10/2017 - 01/2017)
10.	Zeng, Jiawei: 2 articles (10/2017 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dyschromatosis universalis hereditaria:

1.	Dichlorodiphenyldichloroethane (DDD)IBA 08/01/2007 - "We sought to describe several cases of generalized DDD, a presentation that resemble dyschromatosis universalis hereditaria. " 01/01/2023 - "Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH), reticulate acropigmentation of Kitamura (RAK), Dowling-Degos disease (DDD), dyskeratosis congenita (DKC), Naegeli-Franceschetti-Jadassohn syndrome (NFJS), dermatopathia pigmentosa reticularis (DPR), and X-linked reticulate pigmentary disorder. "
2.	Protein Isoforms (Isoforms)IBA 01/01/2017 - "When identifying the causative gene of dyschromatosis universalis hereditaria (DUH), we found three mutations encoding amino acid substitutions in the gene SAM and SH3 domain containing 1 (SASH1), and SASH1 was associated with guanine nucleotide-binding protein subunit-alpha isoforms short (Gαs). "
3.	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 10/01/2017 - "We previously reported that three point mutations in SASH1 and mutated SASH1 promote melanocyte migration in dyschromatosis universalis hereditaria (DUH) and a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. "
4.	Guanine NucleotidesIBA 01/01/2017 - "When identifying the causative gene of dyschromatosis universalis hereditaria (DUH), we found three mutations encoding amino acid substitutions in the gene SAM and SH3 domain containing 1 (SASH1), and SASH1 was associated with guanine nucleotide-binding protein subunit-alpha isoforms short (Gαs). "
5.	Carrier Proteins (Binding Protein)IBA 01/01/2017 - "When identifying the causative gene of dyschromatosis universalis hereditaria (DUH), we found three mutations encoding amino acid substitutions in the gene SAM and SH3 domain containing 1 (SASH1), and SASH1 was associated with guanine nucleotide-binding protein subunit-alpha isoforms short (Gαs). "

Therapies and Procedures

1.	Solid-State Lasers 01/01/2018 - "Removal of forearm lentigines in dyschromatosis universalis hereditaria with a 755-nm Q-switched alexandrite laser." 08/01/2011 - "Removal of facial and labial lentigines in dyschromatosis universalis hereditaria with a Q-switched alexandrite laser."