Okinawa type hereditary motor and sensory Neuropathy

Also Known As:

Neuropathy, hereditary motor and sensory, Okinawa type; HEREDITARY MOTOR AND SENSORY NEUROPATHY, PROXIMAL TYPE; HMSNO; HMSNP

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 14178
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Nervous System Malformations: 35
    - Hereditary Sensory and Motor Neuropathy: 249
      - Okinawa type hereditary motor and sensory Neuropathy: 7
- Inborn Genetic Diseases: 11939
  - Nervous System Heredodegenerative Disorders: 63
    - Hereditary Sensory and Motor Neuropathy: 249
      - Okinawa type hereditary motor and sensory Neuropathy: 7

Related Diseases

1.	Neoplasms (Cancer)
2.	Muscular Atrophy (Muscle Atrophy)
3.	Adenocarcinoma

Experts

1.	Ma, Xing: 2 articles (03/2020 - 11/2013)
2.	Choi, Yongdoo: 2 articles (07/2017 - 05/2017)
3.	Hong, Suk Ho: 2 articles (07/2017 - 05/2017)
4.	Kim, Hyunjin: 2 articles (07/2017 - 05/2017)
5.	Liu, Xiaojia: 1 article (03/2020)
6.	Pan, Xi: 1 article (03/2020)
7.	Sun, Mingze: 1 article (03/2020)
8.	Tang, Xiuzhen: 1 article (03/2020)
9.	Xu, Dandan: 1 article (03/2020)
10.	Yan, Xiaohui: 1 article (03/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Okinawa type hereditary motor and sensory Neuropathy:

1.	Silicon Dioxide (Silica)FDA LinkGeneric 09/28/2022 - "The insulating silica nanoplatform helped investigate the single-dispersed Pd clusters per contact point of Pd@HMSNP at the electrode surface, revealing exceptional HER performance with high maximum turnover numbers and low onset potential for initiating the HER compared to those of SNPs. " 09/28/2022 - "Using insulating silica allowed electron transfer only from the single-dispersed Pd cluster at the contact point of Pd@HMSNP to the electrode. " 05/05/2017 - "Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. " 11/11/2013 - "A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co-delivery system was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer cells for targeted cancer therapy. " 07/18/2022 - "The guanidine carbonate and curcumin are immobilised on the surface of 3-aminopropyl-triethoxy silane (APTES)-decorated hollow mesoporous silica nanoparticles (HMSNP), as confirmed through XPS and NMR analysis. "
2.	Singlet OxygenIBA 05/05/2017 - "Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i.e. " 07/18/2017 - "Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. "
3.	Small Interfering RNA (siRNA)IBA 11/11/2013 - "A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co-delivery system was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer cells for targeted cancer therapy. "
4.	Guanidine (Guanidine Nitrate)FDA Link 07/18/2022 - "The guanidine carbonate and curcumin are immobilised on the surface of 3-aminopropyl-triethoxy silane (APTES)-decorated hollow mesoporous silica nanoparticles (HMSNP), as confirmed through XPS and NMR analysis. "
5.	Photosensitizing Agents (Photosensitizers)IBA 07/18/2017 - "Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. "
6.	SolutionsIBA 09/28/2022 - "Moreover, the high-temporal measurement of SNCEC revealed the diversity of spike shapes based on the heterogeneity of the contact point of Pd@HMSNP, ensuring the capability of the single-entity measurements to distinguish the structure relationship behaviors of the single-dispersed Pd cluster at the electrode/solution interface and clearly clarifying the electron transfer process with complementary information. "
7.	SilanesIBA 07/18/2022 - "The guanidine carbonate and curcumin are immobilised on the surface of 3-aminopropyl-triethoxy silane (APTES)-decorated hollow mesoporous silica nanoparticles (HMSNP), as confirmed through XPS and NMR analysis. "
8.	PolyethyleneimineIBA 11/11/2013 - "Folic acid conjugated polyethyleneimine (PEI-FA) was coated on the HMSNP surfaces under neutral conditions through electrostatic interactions between the partially charged amino groups of PEI-FA and the phosphate groups on the HMSNP surfaces, blocking the mesopores and preventing the loaded drugs from leakage. "
9.	Phosphates (Orthophosphate)IBA 11/11/2013 - "Folic acid conjugated polyethyleneimine (PEI-FA) was coated on the HMSNP surfaces under neutral conditions through electrostatic interactions between the partially charged amino groups of PEI-FA and the phosphate groups on the HMSNP surfaces, blocking the mesopores and preventing the loaded drugs from leakage. "
10.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 05/05/2017 - "Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. "

Therapies and Procedures

1.	Electrodes (Electrode) 09/28/2022 - "The insulating silica nanoplatform helped investigate the single-dispersed Pd clusters per contact point of Pd@HMSNP at the electrode surface, revealing exceptional HER performance with high maximum turnover numbers and low onset potential for initiating the HER compared to those of SNPs. " 09/28/2022 - "Moreover, the high-temporal measurement of SNCEC revealed the diversity of spike shapes based on the heterogeneity of the contact point of Pd@HMSNP, ensuring the capability of the single-entity measurements to distinguish the structure relationship behaviors of the single-dispersed Pd cluster at the electrode/solution interface and clearly clarifying the electron transfer process with complementary information. " 09/28/2022 - "Using insulating silica allowed electron transfer only from the single-dispersed Pd cluster at the contact point of Pd@HMSNP to the electrode. "
2.	Photochemotherapy (Photodynamic Therapy) 07/18/2017 - "In vitro cell studies showed that this HMSNP-based "off-on" agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers."
3.	Precision Medicine 05/05/2017 - "Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. "
4.	Tracheostomy 01/01/2013 - "Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required. "
5.	Therapeutics 11/11/2013 - "A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co-delivery system was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer cells for targeted cancer therapy. "