Acute erythroleukemia

A leukemic or pre-leukemic condition characterized by acute erythroblastic leukemia. Patients may also have elevated IgM and erythrocyte hexokinase levels, as well as marrow hypocellularity and chromosome abnormalities. Familial cases may be associated with mutations in the the EPOR gene. OMIM: 133180

Also Known As:

Networked: 42 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2.	Acute Erythroblastic Leukemia (Erythroleukemia)
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4.	Myelodysplastic Syndromes (Myelodysplastic Syndrome)
5.	Leukemia

Experts

1.	Sharifi, Mohammadreza: 3 articles (08/2019 - 06/2018)
2.	Salehi, Mahsa: 2 articles (08/2019 - 06/2018)
3.	Hasserjian, Robert P: 2 articles (10/2016 - 01/2016)
4.	Patel, Keyur P: 2 articles (10/2016 - 01/2016)
5.	Peng, Jie: 2 articles (10/2016 - 01/2016)
6.	Wang, Sa A: 2 articles (10/2016 - 01/2016)
7.	Chen, Yan: 2 articles (10/2012 - 06/2007)
8.	Bagheri, Marzieh: 1 article (08/2019)
9.	Mortazavi, Deniz: 1 article (12/2018)
10.	Chang, Chun-Kang: 1 article (10/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute erythroleukemia:

1.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/01/2002 - "Complete remission induced by high dose erythropoietin and granulocyte colony stimulating factor in acute erythroleukemia (AML-M6 with maturation)."
2.	ErythropoietinFDA Link 11/01/2002 - "Complete remission induced by high dose erythropoietin and granulocyte colony stimulating factor in acute erythroleukemia (AML-M6 with maturation)."
3.	Therapeutic UsesIBA 06/01/2007 - "The objective of this study was to investigate the biological characteristics and the therapeutic effect in patients with acute erythroleukemia (AML-M(6)). "
4.	MicroRNAs (MicroRNA)IBA 12/01/2018 - "In the present study, upregulation of hsa-let-7c-5p is performed in human acute erythroleukemia cell line (KG-1) using miRNA mimic. " 12/01/2018 - "One of the miRNAs that showed downregulation in human acute erythroleukemia is hsa-let-7c-5p. " 12/01/2018 - "Our results can be used in translational medicine for future investigation in acute erythroleukemia and to approach treatment based on miRNA mimic therapy."
5.	Photosensitizing Agents (Photosensitizers)IBA 12/01/2011 - "In this study, we investigated the killing mechanisms of the photosensitizer ZnPcH1 (a mono-α-substituted zinc(II) phthalocyanine synthesized in China), in the acute lymphoid leukemia cell line Jurkat and the acute erythroleukemia cell line HEL. "
6.	Zn(II)-phthalocyanine (zinc phthalocyanine)IBA 12/01/2011 - "In this study, we investigated the killing mechanisms of the photosensitizer ZnPcH1 (a mono-α-substituted zinc(II) phthalocyanine synthesized in China), in the acute lymphoid leukemia cell line Jurkat and the acute erythroleukemia cell line HEL. "
7.	lambda Spi-1IBA 06/11/1998 - "Spi-1 transcriptional activation and wild-type p53 extinction are two oncogenic alterations involved in the malignant transformation of erythroblasts during the Friend acute erythroleukemia. " 05/01/1996 - "Insertional mutagenesis of the spi-1 gene is associated with the emergence of malignant proerythroblasts during Friend virus-induced acute erythroleukemia. " 06/01/1994 - "During the murine acute erythroleukemia induced by the Friend retrovirus, SFFV, spi-1 deregulation by insertional mutagenesis results in the overexpression of Spi-1/PU.1 in the malignant proerythroblastic cell. "
8.	Long Noncoding RNAIBA 06/01/2018 - "Here, we performed blockage of lncRNA PVT1 in human acute erythroleukemia (AEL) cell line (KG1) using antisense LNA GapmeRs. " 06/01/2018 - "Induction of apoptosis and necrosis in human acute erythroleukemia cells by inhibition of long non-coding RNA PVT1." 08/01/2019 - "Knockdown of Long Noncoding RNA Plasmacytoma Variant Translocation 1 with Antisense Locked Nucleic Acid GapmeRs Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-MYC Expression."
9.	Glycoproteins (Glycoprotein)IBA 07/01/1990 - "The glycoprotein gp55 and its processed form gp65, which are encoded by the env gene of Friend spleen focus-forming virus (SFFV), have been implicated in the initiation of the murine acute erythroleukemia induced by Friend virus (FV). " 01/01/1980 - "The encoding of similar glycoproteins by independently isolated acute erythroleukemia viruses suggests that these glycoproteins may be important in leukemogenesis." 01/01/1980 - "We have described a heterogeneously processed glycoprotein with an apparent molecular weight of 55,000 (gp55) that is encoded by the Friend spleen focus-forming virus, an acute erythroleukemia virus [Dresler, S., Ruta, M., Murray, M.J. "
10.	Glycophorins (Glycophorin C)IBA 05/01/2014 - "Of 84 cases of AML, including cases with megakaryocytic, erythroid, monocytic, and granulocytic differentiation, all five acute erythroleukemia cases were positive, as well as one case of megakaryoblastic leukemia that showed coexpression of glycophorin A. " 05/01/2011 - "Staining of CD71 effectively highlighted pronormoblasts in all 4 cases of parvovirus infection and erythroblasts in all 6 cases of acute erythroleukemia, for which staining of glycophorin A and hemoglobin A was either absent or unreliable. "

Therapies and Procedures

1.	Therapeutics 06/01/2018 - "Our findings can be used in translational medicine for future investigation in acute erythroleukemia and treatment approach based on antisense therapy." 10/12/2017 - "MYCN may serve as a therapy target for the patients with acute erythroleukemia." 10/01/2016 - "Induction chemotherapy was administered to 55% of acute erythroleukemia patients, but was not associated with longer overall survival compared to acute erythroleukemia patients treated with lower-intensity therapies or supportive care (P=0.44). " 01/01/2016 - "Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response." 11/01/1974 - "Development of acute erythroleukemia in B-cell immunoproliferative disorders after prolonged therapy with alkylating drugs."
2.	Drug Therapy (Chemotherapy) 10/01/1978 - "During the course of an acute erythroleukemia chemotherapy drastically reduced SCMC and ADCC activities. " 07/01/1999 - "We performed an HLA-mismatched T cell non-depleted bone marrow transplant on a 53-year-old man with acute erythroleukemia that was highly resistant to conventional remission-induction chemotherapy. " 07/01/1980 - "Acute erythroleukemia following chemotherapy for Hodgkin's disease." 03/01/1977 - "Acute erythroleukemia complicating prolonged chemotherapy for ovarian carcinoma." 08/01/1989 - "A patient in second relapse of acute erythroleukemia (AEL) was treated with 10 MU of recombinant interferon (IFN)-alpha subcutaneously for 24 days after he had failed standard chemotherapy. "
3.	Induction Chemotherapy 10/01/2016 - "Induction chemotherapy was administered to 55% of acute erythroleukemia patients, but was not associated with longer overall survival compared to acute erythroleukemia patients treated with lower-intensity therapies or supportive care (P=0.44). " 10/01/2016 - "Our data show that acute erythroleukemia patients have similar risk-adjusted outcome to refractory anemia with excess blasts patients and do not appear to gain survival advantage with acute myeloid leukemia-type induction chemotherapy. "
4.	Kidney Transplantation 05/01/1979 - "A 53-year-old male developed acute erythroleukemia three years after renal transplantation. "
5.	Transplantation 12/27/2016 - "Transplantation of bone marrow progenitor cells retrovirally engineered to express VENTX caused massive expansion of primitive erythroid cells and partly acute erythroleukemia in transplanted mice. "