Carrington syndrome

Also Known As:

Carrington's Disease; Carrington's pulmonary eosinophilia; Chronic eosinophilic pneumonia (CEP); Chronic idiopathic eosinophilic pneumonia; Eosinophilic idiopathic chronic pneumopathy

Networked: 31 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 6015
- Lung Diseases: 22246
  - Pulmonary Eosinophilia: 1049
    - Carrington syndrome: 31
Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Leukocyte Disorders: 8
    - Eosinophilia: 9570
      - Hypereosinophilic Syndrome: 747
        Pulmonary Eosinophilia: 1049
        Carrington syndrome: 31

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Pulmonary Eosinophilia (Eosinophilic Pneumonia)
3.	Idiopathic Pulmonary Fibrosis
4.	Sarcoidosis (Schaumann Disease)
5.	Cryptogenic Organizing Pneumonia

Experts

1.	Kumamoto, Toshihide: 3 articles (01/2010 - 01/2007)
2.	Matsuno, Osamu: 3 articles (01/2010 - 01/2007)
3.	Miyazaki, Eishi: 3 articles (01/2010 - 01/2007)
4.	Ueno, Takuya: 3 articles (01/2010 - 01/2007)
5.	Shirai, Toshihiro: 2 articles (01/2017 - 06/2015)
6.	Higuchi, Yasunori: 2 articles (01/2010 - 01/2007)
7.	Ando, Masaru: 2 articles (02/2007 - 01/2007)
8.	Nureki, Shinichi: 2 articles (02/2007 - 01/2007)
9.	Aiko, Naoto: 1 article (05/2020)
10.	Baba, Tomohisa: 1 article (05/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Carrington syndrome:

1.	Monoclonal AntibodiesIBA 05/01/2020 - "We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. " 07/23/2023 - "Mepolizumab, a humanized anti IL-5 monoclonal antibody, has been used off-label for chronic eosinophilic pneumonia (CEP), inducing disease remission and saving systemic corticosteroids. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/26/2022 - "Currently, the mainstay of chronic eosinophilic pneumonia (CEP) treatment is corticosteroids, usually with a favorable response and good prognosis. " 01/01/2020 - "Chronic eosinophilic pneumonia (CEP) is an eosinophilic inflammatory disease of unknown etiology, and oral corticosteroid (OCS) is commonly used for its treatment. " 07/01/2003 - "Chronic eosinophilic pneumonia (CEP) is highly sensitive to systemic corticosteroids, but frequently relapses if the dose is tapered or treatment discontinued. " 02/01/1997 - "The prognosis of chronic eosinophilic pneumonia (CEP) is usually good under corticosteroid therapy (CST). " 06/01/1986 - "It is important that physicians not overlook the diagnosis of chronic eosinophilic pneumonia (CEP), since this disorder is readily reversible with corticosteroid therapy. "
3.	Interleukin-5 (Interleukin 5)IBA 07/23/2023 - "Mepolizumab, a humanized anti IL-5 monoclonal antibody, has been used off-label for chronic eosinophilic pneumonia (CEP), inducing disease remission and saving systemic corticosteroids. " 12/01/2017 - "IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis. " 08/01/2004 - "The concentrations of interferon (IFN)-gamma, IL-2, IL-5, IL-10, IL-12, IL-13, and IL-18 in BALF were measured in patients with idiopathic acute eosinophilic pneumonia (AEP), with idiopathic chronic eosinophilic pneumonia (CEP), with sarcoidosis and healthy volunteers (HV). "
4.	benralizumabIBA 11/01/2022 - "Results: The literature we found, largely case reports, reported that the use of benralizumab in EGPA, chronic eosinophilic pneumonia (CEP) and allergic bronchopulmonary aspergillosis (ABPA) often led to a depletion of eosinophils, less exacerbations and a decreased systemic corticosteroid burden. " 05/01/2020 - "We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. "
5.	Interleukin-5 Receptors (Interleukin 5 Receptor)IBA 05/01/2020 - "We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. "
6.	mepolizumabIBA 07/23/2023 - "Mepolizumab, a humanized anti IL-5 monoclonal antibody, has been used off-label for chronic eosinophilic pneumonia (CEP), inducing disease remission and saving systemic corticosteroids. "
7.	SteroidsIBA 07/01/1992 - "We discuss the cases of two patients affected with chronic eosinophilic pneumonia (CEP) pleurisy and eosinophilia in pleural effusion, not previously mentioned in the literature, to point out their peculiarity, to consider differential diagnosis and the effect of steroid therapy. " 01/01/2020 - "Chronic eosinophilic pneumonia (CEP) is a steroid responsive disorder, however, relapses are common following corticosteroid tapering. "
8.	ImmunosorbentsIBA 02/07/2007 - "Serum sCD26 was determined by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity. " 12/01/2017 - "IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis. "
9.	EnzymesIBA 02/07/2007 - "Serum sCD26 was determined by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity. " 12/01/2017 - "IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis. "
10.	Interleukin-33IBA 10/01/2018 - "We investigated the relationships among peripheral blood eosinophil count, serum IL-33 and TSLP concentration, and peripheral blood ILC2 count in patients with EGPA, chronic eosinophilic pneumonia (CEP), or bronchial asthma (BA). " 12/01/2017 - "IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis. "

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "Lessons of the month 2: Chronic eosinophilic pneumonia (CEP): A rare manifestation of infliximab therapy." 02/01/1997 - "The prognosis of chronic eosinophilic pneumonia (CEP) is usually good under corticosteroid therapy (CST). " 06/01/1986 - "It is important that physicians not overlook the diagnosis of chronic eosinophilic pneumonia (CEP), since this disorder is readily reversible with corticosteroid therapy. " 06/01/2015 - "In patients with chronic eosinophilic pneumonia (CEP), dramatic improvements are seen in response to corticosteroid therapy; however, relapse is common after treatment has ceased. " 01/01/1993 - "Chronic eosinophilic pneumonia (CEP) is a rare disorder of unknown etiology characterized by striking systemic and pulmonary manifestations such as fever, weight loss, blood eosinophilia, characteristic fluffy peripheral opacities on chest radiograph, and a prompt response to corticosteroid therapy. "
2.	Bronchoscopes 02/01/1990 - "A case of chronic eosinophilic pneumonia (CEP), confirmed by transfibroptic bronchoscope lung biopsy, was reported. "
3.	Radiotherapy 01/01/2017 - "Reports of chronic eosinophilic pneumonia (CEP) after radiation therapy are limited to breast cancer. "
4.	Aftercare (After-Treatment) 06/01/2015 - "In patients with chronic eosinophilic pneumonia (CEP), dramatic improvements are seen in response to corticosteroid therapy; however, relapse is common after treatment has ceased. "