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of childhood progressive pseudorheumatoid Arthropathy

A hereditary autosomal recessive arthropathy with onset typically by 3 years of age. It is characterized by joint stiffness that first affects the hips, swelling of the fingers, and morning stiffness and decreased mobility of the cervical spine similar to RHEUMATOID ARTHRITIS. However, normal sedimentation rate, negative RHEUMATOID FACTOR tests, and histologically normal SYNOIVUM exclude rheumatoid disease. Patients do not respond to snti-rheumatic drugs and also exhibit radiologic changes indicative of bone dysplasia. Mutations in the WISP3 gene have been identified. OMIM: 208230
Also Known As:
Arthropathy, progressive pseudorheumatoid, of childhood; Progressive pseudorheumatoid arthropathy of childhood; Progressive pseudorheumatoid dysplasia; SEDT-PA; Spondyloepiphyseal dysplasia tarda with progressive arthropathy
Networked: 57 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1. Osteoarthritis
2. of childhood progressive pseudorheumatoid Arthropathy
3. Inborn Genetic Diseases (Disease, Hereditary)
4. Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
5. Pain (Aches)

Experts

1. Xie, Hui: 6 articles (01/2008 - 11/2004)
2. Wang, Min: 5 articles (01/2013 - 11/2004)
3. Liao, Er-Yuan: 4 articles (01/2013 - 01/2005)
4. Zhou, Hou-de: 4 articles (01/2008 - 11/2004)
5. Luo, Xiang-Hang: 3 articles (01/2013 - 01/2005)
6. Zhou, Hou-De: 3 articles (01/2013 - 09/2007)
7. Warman, Matthew L: 3 articles (08/2012 - 01/2005)
8. Peng, Yi-qun: 3 articles (01/2008 - 11/2004)
9. Zhai, Mu-xu: 3 articles (01/2008 - 11/2004)
10. Peng, Yi-Qun: 3 articles (12/2007 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to of childhood progressive pseudorheumatoid Arthropathy:
1. Proteins (Proteins, Gene)FDA Link
2. Complementary DNA (cDNA)IBA
3. Tuberculin (PPD)IBA
4. human CCN6 proteinIBA
5. DNA (Deoxyribonucleic Acid)IBA
6. CollagenIBA
7. Interleukin-10 (Interleukin 10)IBA
8. Interleukin-4 (Interleukin 4)IBA
9. Insulin-Like Growth Factor I (IGF-1)IBA
10. DNA Restriction Enzymes (Restriction Endonuclease)IBA

Therapies and Procedures

1. Hip Replacement Arthroplasty (Total Hip Replacement)
2. Ilizarov Technique