XYY syndrome 47

An extra copy of the Y chromosome in each of a male's cells that arises through GENETIC NON-DISJUNCTION in the embryo. Affected males may be taller than average, but have no other unique physical features; SEXUAL DEVELOPMENT and FERTILITY are unaffected in most cases. 47,XYY syndrome is associated with an increased risk for LEARNING DISORDERS; DEVELOPMENTAL DISABILITIES; HYPOTONIA, and TICS; these characteristics vary widely among affected boys and men. AUTISM SPECTRUM DISORDERS are diagnosed in a minority of cases.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Klinefelter Syndrome (Klinefelter's Syndrome)
2.	Triple X syndrome
3.	Autistic Disorder (Autism)
4.	Turner Syndrome (Turner's Syndrome)
5.	Trisomy (Trisomies)

Experts

1.	Ross, Judith: 2 articles (01/2021 - 12/2012)
2.	Blaskey, Lisa: 1 article (01/2021)
3.	Bloy, Luke: 1 article (01/2021)
4.	Chen, Jiayan: 1 article (01/2021)
5.	Ge, Yunsheng: 1 article (01/2021)
6.	Huang, Yanru: 1 article (01/2021)
7.	Li, Jia: 1 article (01/2021)
8.	Li, Wei: 1 article (01/2021)
9.	Miller, Judith S: 1 article (01/2021)
10.	Roberts, Timothy P L: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to XYY syndrome 47:

1.	dichlorobis(azomycin)platinum IIIBA 10/30/2020 - "Conclusions: The results of present study showed 100% PPV effectiveness of NIPT Panorama test detecting trisomies of 21 and 18 chromosomes, as well as XYY syndrome in the studied cohort. " 01/01/2021 - "Expanded NIPT detected 45,X, 47,XXX, 47,XXY, XYY syndrome, RATs, and CNVs with positive predictive values of 25.49%, 75%, 94.12%, 76.19%, 6.45%, and 50%, respectively. " 10/30/2020 - "The overall positive predictive value (PPV) of NIPT for trisomy 21 (n = 9), trisomy 18 (n = 3) and XYY syndrome (n = 1) was 100%. " 01/01/2020 - "The positive predictive value (PPV) of NIPT in the present study was 57.6%, which was divided and categorized by individual SCAs as follows: 21.4% for Turner syndrome (45,X), 75.0% for Triple X syndrome (47,XXX), 90.9% for Klinefelter syndrome (47,XXY), and 75.0% for XYY syndrome (47,XYY). "
2.	gamma-Aminobutyric Acid (GABA)IBA 01/01/2021 - "In this study, we investigated the associations of genotype and clinical phenotype with levels of GABA, estimated by regionally localized edited magnetic resonance spectroscopy in boys with 47, XYY syndrome compared to age-matched typically developing (XY) peers. " 01/01/2023 - "While SVR models accounted for ~80% of the M50 latency variance in TD and the genetically homogenous XYY syndrome, a similar approach only accounted for ~20% of the M50 latency variance in ASD, implicating the insufficiency of diffusion MR, GABA MRS, and age factors alone. " 01/01/2023 - "The goal of this study is to use neuroimaging (diffusion MR and GABA MRS) measures to predict auditory conduction velocity in typically developing (TD) children and children with autism ASD and XYY syndrome. "
3.	Prostaglandins DIBA 08/05/2018 - "Between January 2012 and May 2017, 51 infertile males with nonmosaic 47,XYY syndrome underwent FISH-PGD were included in the study. " 01/01/2011 - "(1) Karyotypic analysis of both partners is a sine qua non investigation for recurrent miscarriages; (2) the XYY syndrome results in high frequency of embryo aneuploidy; (3) PGD by FISH can contribute to the transferring of chromosomally normal embryos in cases of parental chromosomal defects; (4) investigation for a prolactinoma should be considered in men with XYY syndrome."
4.	Growth Hormone (Somatotropin)IBA 12/01/2020 - "Pathological causes for tall statute include endocrine disorders, such as excessive growth hormone secretion, hyperthyroidism, precocious puberty and lipodystrophy, chromosome disorders, such as Trisomy X (47, XXX female), Klinefelter Syndrome (47, XXY), XYY syndrome (47, XYY male) and fragile X syndrome, and syndromes and metabolic disorders, such as Marfan Syndrome, Beckwith-Wiedemann Syndrome, Simpson-Golabi-Behmel Syndrome, Sotos Syndrome and homocystinuria. " 12/01/1969 - "Serum growth hormone level after oral glucose load, urinary excretion of pituitary gonadotrophin and 17-ketosteroids in XYY syndrome." 09/01/2015 - "Various pathologic conditions leading to adult tall stature include excess growth hormone secretion, Marfan syndrome, androgen or estrogen deficiency, testicular feminization, and sex chromosome anomaly, such as Klinefelter syndrome and XYY syndrome. "
5.	17-Ketosteroids (17 Ketosteroids)IBA 01/01/1973 - "Pituitary gonadotrophins and 17-ketosteroids in patients with the XYY syndrome." 12/01/1969 - "Serum growth hormone level after oral glucose load, urinary excretion of pituitary gonadotrophin and 17-ketosteroids in XYY syndrome."
6.	Testosterone (Sustanon)FDA Link 08/15/1970 - "Gonadotrophins and testosterone in the XYY syndrome."
7.	Gonadal Steroid Hormones (Sex Hormones)IBA 01/01/2020 - "47,XYY syndrome was associated with a significantly increased occurrence of prescriptions overall (hazard ratio = 1.25, CI: 1.10-1.44), with sex hormones and medication related to the urogenital system, blood, and nervous system being most prominently increased. "
8.	Quinacrine (Mepacrine)IBA 03/01/1974 - "[Identification of the XYY syndrome by quinacrine dihydrochloride fluorescence staining]."
9.	Methotrexate (Mexate)FDA LinkGeneric 01/01/1997 - "Their tolerance of intensive treatment, including high-dose methotrexate, suggests that the untoward treatment toxicity seen in patients with chromosomal abnormalities such as trisomy 21 does not extend to the XYY syndrome."
10.	Luteinizing Hormone (Lutropin)FDA LinkGeneric 12/01/1973 - "Urinary follicle stimulating hormone and luteinizing hormone in six males with the XYY syndrome."

Therapies and Procedures

1.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 07/01/2002 - "Severe regimen-related toxicity occurring in a patient with XYY syndrome receiving allogeneic peripheral blood stem cell transplantation."
2.	Transplantation 07/01/2002 - "Patients with XYY syndrome might have a high risk of transplantation-related mortality."
3.	Therapeutics 03/15/2010 - "A four-year-old boy with XYY syndrome developed signs and symptoms consistent with early NMS after three weeks of quetiapine therapy. " 03/15/2010 - "A case of early neuroleptic malignant syndrome (NMS) in a child with XYY syndrome after three weeks of quetiapine therapy is reported. "
4.	Institutionalization (Institutionalized Persons) 05/01/1972 - "47,XYY syndrome, height and institutionalization of juvenile delinquents."
5.	Drug Therapy (Chemotherapy) 01/01/2005 - "During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. "