Recurrent respiratory papillomatosis

A rare disease characterized by PAPILLOMA growth in the respiratory tract. The tumors may vary in size, grow very quickly, and often grow back even when removed. They are caused by HUMAN PAPILLOMAVIRUS 6 and HUMAN PAPILLOMAVIRUS 11 infections.

Also Known As:

Networked: 444 relevant articles (47 outcomes, 48 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Disease Progression
2.	Neoplasms (Cancer)
3.	Rubella (German Measles)
4.	Mumps
5.	Measles

Experts

1.	Derkay, Craig S: 10 articles (05/2022 - 05/2003)
2.	Dikkers, Frederik G: 9 articles (09/2022 - 05/2006)
3.	Wang, Jun: 9 articles (01/2022 - 03/2002)
4.	Smith, Richard J H: 6 articles (03/2022 - 11/2002)
5.	Rosen, Clark A: 6 articles (05/2021 - 06/2004)
6.	Onufrieva, E K: 6 articles (01/2011 - 01/2000)
7.	Soldatskiĭ, Iu L: 6 articles (01/2011 - 01/2000)
8.	Allen, Clint T: 5 articles (10/2022 - 01/2017)
9.	Best, Simon R: 5 articles (05/2022 - 09/2012)
10.	Ma, Lijing: 5 articles (01/2022 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Recurrent respiratory papillomatosis:

1.	Cidofovir (Vistide)FDA Link 01/01/2012 - "Intralesional cidofovir appears to be effective in the treatment of recurrent respiratory papillomatosis, although further studies are required to determine its safety." 11/01/2010 - "The efficacy of cidofovir in juvenile recurrent respiratory papillomatosis (JRRP) remains uncertain due to the lack of published case-control studies. " 11/01/2010 - "Efficacy of cidofovir in recurrent juvenile respiratory papillomatosis." 07/01/2006 - "To investigate the efficacy of intralesional cidofovir in the treatment of recurrent respiratory papillomatosis (RRP) in children. " 12/01/2004 - "To evaluate the efficacy of intralesional cidofovir injection for the treatment of recurrent respiratory papillomatosis (RRP). "
2.	Bevacizumab (Avastin)FDA Link 06/01/2023 - "This study aims to systematically review the literature on efficacy of intralesional Bevacizumab in juvenile onset respiratory papillomatosis. " 07/20/2023 - "Efficacy of Systemic Bevacizumab for Recurrent Respiratory Papillomatosis with Pulmonary Involvement." 10/01/2021 - "The goal of this study was to evaluate the benefit of sublesional bevacizumab injection for recurrent respiratory papillomatosis (RRP) as used in a typical clinical practice. " 01/01/2021 - "The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality. " 12/01/2023 - "A case report describing the use of systemic bevacizumab in the treatment of recurrent respiratory papillomatosis with pulmonary involvement."
3.	Antiviral Agents (Antivirals)IBA 06/01/2007 - "To determine the efficacy of antiviral agents for recurrent respiratory papillomatosis (RRP) in children and adults. " 06/01/2007 - "Antiviral agents for the treatment of recurrent respiratory papillomatosis: a systematic review of the English-language literature." 12/12/2012 - "There is insufficient evidence to support the efficacy of antiviral agents as adjuvant therapy in the management of recurrent respiratory papillomatosis in children or adults. " 01/20/2010 - "There is insufficient evidence to support the efficacy of antiviral agents as adjuvant therapy in the management of recurrent respiratory papillomatosis in children or adults. " 10/19/2005 - "There was insufficient evidence from controlled trials on which to base reliable conclusions about the effectiveness of antiviral agents as adjuvant therapy in the management of recurrent respiratory papillomatosis. "
4.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/01/2019 - ": To explore the efficacy of microsurgery in combined with Topical-PDT in treating recurrent respiratory papillomatosis.Materials" 12/01/2019 - "Efficacy of microsurgery in combined with topical-PDT in treating recurrent respiratory papillomatosis: compare JORRP with AORRP." 08/01/1994 - "We investigated photodynamic therapy (PDT) as an alternative treatment modality for recurrent respiratory papillomatosis. " 01/01/2019 - "In this report, we describe a 27-year-old male patient with recurrent respiratory papillomatosis who was treated with CO2 laser therapy followed by 5-aminolevulinic acid photodynamic therapy (ALA-PDT). " 06/01/2016 - "This article describes the case of 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) via self-retaining laryngoscope under general anesthesia combined with CO2 Laser Therapy in the treatment of three patients with juvenile laryngeal papilloma. "
5.	Papillomavirus Vaccines (HPV Vaccines)IBA 02/01/2014 - "Prolonged remission of juvenile-onset respiratory papillomatosis: a post-expositional role of the tetravalent anti-HPV vaccine?" 01/01/2019 - "The present study supports the continued use of the HPV vaccine as an adjuvant treatment for recurrent respiratory papillomatosis." 09/16/2022 - "This systematic literature review identifies and synthesizes the evidence of the real-world impact and effectiveness of the quadrivalent and nonavalent HPV vaccines in high-risk populations: women with prior/current HPV-related anogenital disease, men who have sex with men, immunocompromised/immunosuppressed individuals, female sex workers, transgender and non-binary individuals, and patients with recurrent respiratory papillomatosis (RRP). " 02/05/2019 - "[Research status of human papillomavirus vaccine for prevention and treatment of respiratory papillomatosis]." 11/24/2017 - "Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature."
6.	Interferon-alpha (Interferon Alfa)IBA 08/18/1988 - "We evaluated the efficacy of human leukocyte interferon in the treatment of respiratory papillomatosis. " 06/01/2005 - "The aim of this study was analysis of the results of use of interferon-alpha (IFN-alpha) in patients with recurrent respiratory papillomatosis (RRP) and correlation of the results with human papillomavirus (HPV) type. " 06/01/2005 - "Use of interferon-alpha in recurrent respiratory papillomatosis: 20-year follow-up." 06/01/2005 - "Human papillomavirus, viral load and proliferation rate in recurrent respiratory papillomatosis in response to alpha interferon treatment." 12/05/1999 - "Effective adjuvant treatment for recurrent respiratory papillomatosis (RRP) is at present limited to alpha-interferon, which may have significant side effects including rebound growth of papillomata following its withdrawal, is given by injection and is expensive. "
7.	indole-3-carbinolIBA 06/01/1998 - "Indole-3-carbinol is a chemical that is found in high concentrations in cruciferous vegetables and has been shown to alter the growth pattern of recurrent respiratory papillomatosis cell cultures and to be effective in an in vivo animal model of recurrent respiratory papillomatosis. " 06/01/1998 - "We report the preliminary results of a phase I trial using indole-3-carbinol for the treatment of recurrent respiratory papillomatosis. " 01/01/2011 - "It is concluded that treatment with indole-3-carbinol can be recommended as a starting therapeutic modality for the management of juvenile recurring respiratory papillomatosis and the reduction of the intervals between relapses of the disease." 06/01/2004 - "We report the results of a clinical study using Indole-3-Carbinol (I3C) for the treatment of recurrent respiratory papillomatosis (RRP). " 06/01/2004 - "Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results."
8.	Measles-Mumps-Rubella Vaccine (MMR Vaccine)IBA 04/01/2012 - "Topical measles-mumps-rubella vaccine in the treatment of recurrent respiratory papillomatosis: results of a preliminary randomized, controlled trial." 03/01/2019 - "To evaluate the efficacy of MMR vaccine in the treatment of juvenile-onset recurrent respiratory papillomatosis as adjuvant therapy by experimental research. " 04/01/2012 - "We conducted a study to test the hypothesis that the measles-mumps-rubella (MMR) vaccine can either prevent further recurrences of recurrent respiratory papillomatosis (RRP) or prolong its remission. " 03/01/2019 - "Experimental research on the therapeutic effect of MMR vaccine to juvenile-onset recurrent respiratory papillomatosis."
9.	Photosensitizing Agents (Photosensitizers)IBA 03/01/2010 - "To evaluate the efficacy of photodynamic therapy (PDT) with the phthalocyanine photosensitizer Pc 4 for treating an animal model of recurrent respiratory papillomatosis (RRP). " 02/01/2005 - "To determine the efficacy of photodynamic therapy (PDT) with meso-tetra (hydroxyphenyl) chlorin (m-THPC) photosensitizer for recurrent respiratory papillomatosis. "
10.	InterferonsIBA 06/01/2005 - "The aim of this study was to identify recurrent respiratory papillomatosis patients who may benefit from interferon (IFN)-alpha treatment and to determine the means of IFN-alpha action. " 07/01/2018 - "Pegylated interferon may be a good option for diminishing the need for surgical intervention in severe cases of recurrent respiratory papillomatosis." 07/01/2018 - "Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report." 09/01/2004 - "Interferon alpha-2b as adjuvant treatment of recurrent respiratory papillomatosis in Cuba: National Programme (1994-1999 report)." 09/01/1991 - "[Natural killer activity in respiratory papillomatosis and its changes after interferon treatment]."

Therapies and Procedures

1.	Therapeutics 08/01/2002 - "Many adjuvant therapies have been investigated but no single treatment modality proved to be effective in eradicating recurrent respiratory papillomatosis. " 01/01/2023 - "To characterize the efficacy of human papillomavirus (HPV) vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP). " 01/01/2023 - "The Efficacy of Human Papillomavirus Vaccination as an Adjuvant Therapy in Recurrent Respiratory Papillomatosis." 01/01/2017 - "Objective Given the recalcitrant nature of recurrent respiratory papillomatosis, targeted therapies to reduce disease burden are fundamental to improved patient care paradigms. " 01/01/2006 - "[Efficacy of indinol in antirecurrence therapy of juvenile respiratory papillomatosis]."
2.	Gas Lasers 07/01/2023 - "To compare the efficacy of two main treatment modalities of microdebrider and carbon dioxide laser excision for juvenile onset recurrent respiratory papillomatosis. " 01/01/2003 - "The mainstay of treatment of children with recurrent respiratory papillomatosis has been CO2 laser laryngoscopy. " 05/01/2010 - "We aimed to study the efficacy of radiofrequency cold ablation (coblation) for the treatment of laryngotracheal recurrent respiratory papillomatosis, by comparing treatment intervals for coblation and CO2 laser vaporisation. " 12/01/2001 - "To study the clinical behavior of juvenile-onset recurrent respiratory papillomatosis in order to find some factors correlated to the development of this disease, and to sum up the significance and experience of CO2 laser surgery. " 07/01/2023 - "Microdebrider was found to be superior to carbon dioxide laser excision in the treatment of juvenile onset recurrent respiratory papillomatosis."
3.	Photochemotherapy (Photodynamic Therapy) 07/01/1998 - "Efficacy of DHE photodynamic therapy for respiratory papillomatosis: immediate and long-term results." 06/05/2014 - "There is insufficient evidence from high-quality randomised controlled trials to determine whether photodynamic therapy alters the course of disease or provides an added benefit to surgery in patients with recurrent respiratory papillomatosis. " 06/05/2014 - "To assess the effects of photodynamic therapy in the management of recurrent respiratory papillomatosis (RRP) in children and adults. " 06/05/2014 - "Photodynamic therapy for recurrent respiratory papillomatosis." 01/01/2011 - "The potential of photodynamic therapy for the treatment of recurrent respiratory papillomatosis remains to be elucidated. "
4.	Intralesional Injections 09/01/2006 - "We assessed the intermediate-term and long-term efficacy of intralesional injection of cidofovir used with surgical excision in juvenile-onset recurrent respiratory papillomatosis. " 06/01/2003 - "We sought to determine the efficacy of intralesional injection of cidofovir in improving resolution of recurrent respiratory papillomatosis (RRP). " 05/01/2009 - "The results of the study indicate that intralesional injections of cidofovir can be an effective method of treatment for recurrent respiratory papillomatosis in children." 05/01/2009 - "Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children." 11/01/2006 - "Intralesional injection of cidofovir has been described as an adjunctive treatment for pediatric recurrent respiratory papillomatosis (RRP). "
5.	Solid-State Lasers 08/01/2007 - "The 532 nm pulsed-KTP laser was effective for treating recurrent respiratory papillomatosis, which was similar to our experience as an office-based procedure." 04/01/2021 - "Longitudinal Voice Outcomes Following Serial Potassium Titanyl Phosphate Laser Procedures for Recurrent Respiratory Papillomatosis." 07/01/2004 - "A follow-up period of 1 year revealed that Nd:YAG laser surgery seems to prevent a rapid recurrence of juvenile respiratory papillomatosis in the treated patients." 07/01/2004 - "Preliminary report of endolaryngeal and endotracheal laser surgery of juvenile-onset recurrent respiratory papillomatosis by Nd:YAG laser and a new fiber guidance instrument." 12/01/2008 - "Two patients diagnosed with recurrent respiratory papillomatosis at age 6-15 mo underwent multiple CO(2) and KTP laser ablations of laryngotracheal papillomas. "