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UA 62784

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inhibits centromere protein E kinesin-like protein; structure in first source

Also Known As:

UA-62784; UA62784

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Oxazoles: 5
      - UA 62784: 5
- 3-Ring Heterocyclic Compounds
  - Xanthenes: 7
    - Xanthones: 80
      - UA 62784: 5

Experts

1.	Han, Haiyong: 3 articles (11/2009 - 01/2009)
2.	Flynn, Gary: 2 articles (11/2009 - 01/2009)
3.	Dorr, Robert T: 2 articles (11/2009 - 01/2009)
4.	Henderson, Meredith C: 2 articles (11/2009 - 01/2009)
5.	Hurley, Laurence H: 2 articles (11/2009 - 01/2009)
6.	Wang, Hong: 2 articles (07/2009 - 01/2009)
7.	Von Hoff, Daniel D: 2 articles (07/2009 - 01/2009)
8.	Sarli, Vasiliki: 1 article (05/2011)
9.	Calligaris, David: 1 article (05/2011)
10.	Abrieu, Ariane: 1 article (05/2011)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 05/27/2011 - "A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. " 11/01/2009 - "A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one] was synthesized with the intention of improving upon the selective cytotoxicity of UA-62784 against human pancreatic cancer cell lines with a deletion of the tumor suppressor gene deleted in pancreas cancer locus 4 (DPC-4, SMAD-4). " 05/27/2011 - "A paper in this issue of Chemistry & Biology shows that the diaryl oxazole compound UA62784 that targets pancreatic cancer cells interacts with tubulin near the colchicine binding site (Tcherniuk et al., 2011). " 11/01/2009 - "Despite a structural relationship to UA-62784, which inhibits the mitotic kinesin centromere protein E (CENP-E), none of the analogs was selective for DPC-4-deleted pancreatic cancer cell lines. "
2.	Neoplasms (Cancer) 07/01/2009 - "UA62784 is a small molecule that selectively kills DPC4-deficient cancer cells. " 07/01/2009 - "A lead molecule, UA62784, was identified to be selectively cytotoxic against cancer cells with deficient DPC4. "
3.	Carcinoma (Carcinomatosis) 01/01/2009 - "UA62784 was isolated due to its selectivity in isogenic pancreatic carcinoma cell lines with a deletion of the DPC4 gene. " 01/01/2009 - "UA62784 is a novel specific inhibitor of CENP-E and its activity suggests a potential role for antimitotic drugs in treating pancreatic carcinomas."

Related Drugs and Biologics

1.	Antimitotic Agents
2.	Kinesin
3.	Tubulin
4.	Colchicine
5.	centromere protein E