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1,1- bis(3'- indolyl)- 1- (4- chlorophenyl)methane

activates Nurr1; has antineoplastic activity; structure in first source

Also Known As:

1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane; DIM-C-pPhCl

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane: 3

Experts

1.	Safe, Stephen: 3 articles (01/2020 - 12/2008)
2.	Li, Xi: 2 articles (01/2020 - 10/2019)
3.	Jin, Un-Ho: 1 article (01/2020)
4.	Karki, Keshav: 1 article (01/2020)
5.	Michelhaugh, Sharon K: 1 article (01/2020)
6.	Mittal, Sandeep: 1 article (01/2020)
7.	Mohankumar, Kumaravel: 1 article (01/2020)
8.	Tjalkens, Ronald: 1 article (01/2020)
9.	Zarei, Mahsa: 1 article (01/2020)
10.	Shrestha, Rupesh: 1 article (10/2019)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/2019 - "In this study, the effects of DIM-C-pPhCl and related analogs were compared with CQ/AQ as inducers of NR4A2-responsive genes including vasoactive intestinal peptide, osteopontin, proopiomelanocortin, and neuropilin 1 in Panc1 and Panc28 pancreatic cancer cells. "
2.	Glioblastoma (Glioblastoma Multiforme) 01/01/2020 - "The NR4A2 ligand, 1,1-bis (31-indoly1)-1-(p-chlorophenyl)methane (DIM-C-pPhCl) inhibits markers of neuroinflammation and degeneration in mouse models and in this study we investigated expression and function of NR4A2 in glioblastoma (GBM). "
3.	Neuroinflammatory Diseases 01/01/2020 - "The NR4A2 ligand, 1,1-bis (31-indoly1)-1-(p-chlorophenyl)methane (DIM-C-pPhCl) inhibits markers of neuroinflammation and degeneration in mouse models and in this study we investigated expression and function of NR4A2 in glioblastoma (GBM). "
4.	Parkinson Disease (Parkinson's Disease) 10/01/2019 - "Bis-indole derivatives including 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane (DIM-C-pPhCl) and substituted quinolines such as chloroquine (CQ) and amodiaquine (AQ) are nuclear receptor 4A2 (NR4A2, Nurr1) ligands, and they exhibit anti-inflammatory activities in mouse and rat models of Parkinson's disease, respectively. "
5.	Neoplasms (Cancer) 01/01/2020 - "NR4A2 knockdown and DIM-C-pPhCl inhibited GBM cell and tumor growth, induced apoptosis and inhibited migration and invasion of GBM cells. "

Related Drugs and Biologics

1.	Ligands
2.	Osteopontin
3.	Neuropilin-1
4.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
5.	Pro-Opiomelanocortin (Proopiomelanocortin)
6.	1,1- bis(3'- indolyl)- 1- (4- chlorophenyl)methane
7.	Member 2 Group A Nuclear Receptor Subfamily 4
8.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
9.	Quinolines
10.	Chloroquine (Aralen)