frondoside A

10/01/2011 - "These findings identify Frondoside A as a promising novel therapeutic agent for breast cancer."
04/01/2012 - "Using a syngeneic murine model of metastatic breast cancer, we now show that Frondoside A has potent antimetastatic activity. "
10/01/2011 - "Frondoside A (0.01-5 μM) decreased the viability of breast cancer cells in a concentration- and time-dependent manner, with 50%-effective concentration (EC50) of 2.5 μM at 24h. "
10/01/2011 - "Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts."
09/01/2012 - "These results indicate the role of frondoside A in metastasis and its underlying molecular mechanisms, thus, suggesting frondoside A as a chemopreventive agent for metastatic breast cancer."

01/01/2013 - "These findings identify Frondoside A as a promising novel therapeutic agent for lung cancer."
01/01/2023 - "Retraction: Frondoside A Suppressive Effects on Lung Cancer Survival, Tumor Growth, Angiogenesis, Invasion, and Metastasis."
01/01/2013 - "Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis."
05/01/2018 - "Over recent years, we have demonstrated that Frondoside A, a triterpenoid glycoside isolated from an Atlantic sea cucumber, has potent in vitro and in vivo anti-cancer effects against human pancreatic, breast, and lung cancer. "
05/30/2017 - "A sulfated saponin called "Frondoside A" (FRA) from sea cucumber and ingredients from Okinawa propolis (OP) have been previously shown to suppress the PAK1-dependent growth of A549 lung cancer as well as pancreatic cancer cells. "

06/17/2016 - "Based on the current and previous studies, frondoside A appears safe and may be valuable in the treatment of cancer. "
04/01/2012 - "These studies add to the growing body of evidence that Frondoside A may be a promising new agent with potential to treat cancer and may also represent a potential new modality to antagonize EP4."
01/11/2023 - "It has been demonstrated that Frondoside A exhibits anti-proliferative, anti-invasive, anti-angiogenic, anti-cancer, and potent immunomodulatory effects. "
02/19/2018 - "Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities."
02/19/2018 - "The Anti-Cancer Effects of Frondoside A."

12/01/2017 - "Frondoside A may be valuable in the treatment of acute leukemia, particularly when used in combination with current therapeutic drugs."
12/01/2017 - "Frondoside A potentiates the effects of conventional therapeutic agents in acute leukemia."
12/01/2017 - "The current study investigated the effects of frondoside A in acute leukemia cell lines alone and in combination with drugs used for this malignancy. "
02/18/2009 - "Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells."

05/01/2018 - "This study evaluates the impact of Frondoside A alone and in combination with the standard cytotoxic drugs oxaliplatin and 5-fluorouracil (5-FU) in the treatment of colon cancer using three human colon cancer cell lines, namely, HT-29, HCT-116, and HCT8/S11. "
05/01/2018 - "The reduction in cell numbers by Frondoside A, oxaliplatin, and 5-FU was also confirmed in two other colon cancer cell lines, namely, HCT8/S11 and HCT-116, treated for 48 h. "
05/01/2018 - "We demonstrate that Frondoside A, oxaliplatin, and 5-FU cause a concentration- and time-dependent reduction in the number of HT-29 colon cancer cells. "
05/01/2018 - "In light of these findings, we strongly suggest that Frondoside A may have a role in colon cancer therapy when used in combination with the standard cytotoxic drugs oxaliplatin and 5-FU."
05/01/2018 - "Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells."