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1- butyl- 8- (3- noradamantyl)- 3- (3- hydroxypropyl)xanthine

an A1 receptor antagonist

Also Known As:

PSB 36; PSB-36; PSB36 cpd

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - 1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine: 2

Experts

1.	Bednarska-Szczepaniak, Katarzyna: 1 article (01/2019)
2.	Klink, Magdalena: 1 article (01/2019)
3.	Krzyżanowski, Damian: 1 article (01/2019)
4.	Nowak, Marek: 1 article (01/2019)
5.	Abo-Salem, Osama M: 1 article (03/2008)
6.	Bilkei-Gorzo, Andras: 1 article (03/2008)
7.	Hayallah, Alaa M: 1 article (03/2008)
8.	Michel, Kerstin: 1 article (03/2008)
9.	Müller, Christa E: 1 article (03/2008)
10.	Zimmer, Andreas: 1 article (03/2008)

Related Diseases

1.	Inflammation (Inflammations) 03/01/2008 - "In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. "
2.	Hyperalgesia 03/01/2008 - "In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2019 - "PSB 36, an A1 receptor antagonist, sensitized cisplatin-resistant ovarian cancer cells to cisplatin from low to high micromolar concentrations. "
4.	Neoplasms (Cancer) 01/01/2019 - "In contrast to PSB 36, the A2AR antagonist ZM 241385 had the opposite effect and reduced the influence of cisplatin on cancer cells, increasing their resistance to cisplatin cytotoxicity, decreasing cisplatin uptake, inhibiting cisplatin-induced cell cycle arrest, and partly restoring mitochondrial and plasma membrane potentials that were disturbed by cisplatin. "

Related Drugs and Biologics

1.	Purinergic P1 Receptor Antagonists
2.	1-propyl-8-(4-sulfophenyl)xanthine
3.	Cisplatin (Platino)
4.	ZM 241385 (ZM241385)