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N- (4- methoxyphenyl)- 4- menthone- 3- carboxamide

a TRPM8 agonist and analgesic; structure in first source

Also Known As:

N-(4-methoxyphenyl)-p-menthone-3-carboxamide; WS 12 compound; WS-12; WS-12 compound; WS12 compound

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fujino, H: 1 article (08/2014)
2.	Horie, S: 1 article (08/2014)
3.	Hosoya, T: 1 article (08/2014)
4.	Matsumoto, K: 1 article (08/2014)
5.	Murayama, T: 1 article (08/2014)
6.	Nakamura, H: 1 article (08/2014)
7.	Tashima, K: 1 article (08/2014)
8.	Balakrishna, Shrilatha: 1 article (10/2013)
9.	Fan, Lu: 1 article (10/2013)
10.	Jordt, Sven-Eric: 1 article (10/2013)

Related Diseases

1.	Acidosis 10/01/2008 - "In addition, acidosis or variations in extracellular calcium have no influence on potency/efficacy of WS-12 for TRPM8. "
2.	Prostatic Neoplasms (Prostate Cancer) 10/01/2008 - "The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer." 12/01/2007 - "Here we characterise the effects of the carboxamides WS-12, CPS-113, CPS-369, the carboxylic acid WS-30 and the phosphine oxide WS-148 by Ca2+ imaging experiments and whole-cell patch-clamp recordings on TRPM8 expressing human embryonic kidney (HEK), lymph node prostate cancer (LNCaP) and dorsal root ganglia (DRG) cells. "
3.	Visceral Pain 08/01/2014 - "Intracolonic administration of WS-12 induced behavioral visceral pain-like responses. "
4.	Stroke (Strokes) 01/01/2012 - "The item for running in the WS-12 was also often commented on as being not possible before stroke. "
5.	Tachycardia (Tachyarrhythmias) 01/01/2023 - "WS-12 reduced AITC-evoked tachycardia and PVCs in SH rats, but this more potent TRPM8 agonist also reduced AITC-evoked bradycardia. " 01/01/2023 - "Irritant-evoked reflex tachyarrhythmia in spontaneously hypertensive rats is reduced by inhalation of TRPM8 agonists l-menthol and WS-12." 01/01/2023 - "We found that inhalation of TRPM8 agonists, l-menthol and WS-12, but not the inactive analog d-menthol, selectively reduces the reflex tachyarrhythmia evoked by allyl isothiocyanate (AITC) inhalation in SH rats. "

Related Drugs and Biologics

1.	Calcium
2.	Menthol
3.	Oxides
4.	Irritants (Vesicants)
5.	Dextrans (Dextran)
6.	Carboxylic Acids
7.	phosphine (phosphane)
8.	2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate (AITC)
9.	sodium sulfate (sodium bisulfate)
10.	allyl isothiocyanate

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia