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ZT-031

a cyclic 31-amino acid analog of parathyroid hormone(1-31) for the potential treatment of osteoporosis

Also Known As:

Ostabolin-C; cyclic PTH-(1-31),(Leu27)-cyclo(Glu22-Lys26)-hPTH(1-31)NH2,

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Parathyroid Hormone: 11951
      - ZT-031: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Hormones: 1347
    - Parathyroid Hormone: 11951
      - ZT-031: 1
  - Cyclic Peptides: 530
    - ZT-031: 1
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - ZT-031: 1

Experts

1.	Nemeth, Edward F: 1 article (11/2008)

Related Diseases

1.	Osteoporosis 11/01/2008 - "The daily subcutaneous administration of ZT-031 to postmenopausal women with osteoporosis elicited a dose-dependent increase in BMD of the lumbar spine, proximal femur and total hip area. " 11/01/2008 - "ZT-031, a cyclized analog of parathyroid hormone(1-31) for the potential treatment of osteoporosis." 11/01/2008 - "Daily subcutaneous injections of ZT-031 prevented bone loss and replaced bone that had already been lost in an ovariectomized rat model of osteoporosis. " 11/01/2008 - "ZT-031 is a cyclic 31-amino acid analog of parathyroid hormone (PTH) that is in development by Zelos Therapeutics Inc for the treatment of osteoporosis and other bone-related disorders. "
2.	Hypercalcemia (Milk Alkali Syndrome) 11/01/2008 - "ZT-031 was demonstrated to be safe and well tolerated; episodes of hypercalcemia were infrequent and observed with a frequency greater than with placebo only at the highest doses tested for the drug. "

Related Drugs and Biologics

1.	Parathyroid Hormone (Parathormone)
2.	Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Subcutaneous Injections