crotalphine

11/01/2016 - "The aim of the present study was to investigate the effect of crotalphine on ion channels in peripheral pain pathways. "
11/22/2021 - "Crotalphine Attenuates Pain and Neuroinflammation Induced by Experimental Autoimmune Encephalomyelitis in Mice."

11/15/2023 - "PERSPECTIVE: Our work identified that crotalphine-induced activation of CB2 receptors plays a critical role in the impairment of Wnt signaling during neuropathic pain. "
10/10/2008 - "In the present work, the antinociceptive effect of crotalphine was evaluated in an experimental model of neuropathic pain induced in rats by chronic constriction of sciatic nerve. "
11/15/2023 - "Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain."
09/30/2022 - "Thus, the central effect of crotalphine was evaluated on the partial sciatic nerve ligation (PSNL)-induced chronic neuropathic pain model. "
10/10/2008 - "Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors."

02/01/2012 - "Crotalphine (0.2 or 5 μg/kg, orally; 0.0006 μg/paw), administered on day 14 after nerve constriction, inhibited mechanical hyperalgesia and low-threshold mechanical allodynia. "
08/01/2008 - "In the mechanical hyperalgesia models, crotalphine shows a long-lasting (5 days) antinociceptive effect. "
11/01/2016 - "Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia."
02/01/2014 - "(0.008-1.0 μg·kg(-1) ) and intraplantar (0.0006 μg per paw) administration of crotalphine induced antinociception in PGE2 -induced hyperalgesia. "
08/01/2008 - "Crotalphine, when orally administered (0.008-25mug/kg), induces antinociceptive effect in the prostaglandin E(2)- and carrageenin-induced mechanical hyperalgesia models in rats and in the hot-plate test in mice. "

11/22/2021 - "Crotalphine Attenuates Pain and Neuroinflammation Induced by Experimental Autoimmune Encephalomyelitis in Mice."
11/15/2023 - "Taken together, our findings show that crotalphine induces analgesia in a neuropathic pain model by down-regulating the canonical Wnt/β-catenin and the atypical Wnt/Ryk signaling pathways and, consequently controlling neuroinflammation. "
09/30/2022 - "These results demonstrated that crotalphine, besides activating opioid and cannabinoid analgesic systems, impairs central neuroinflammation, confirming the neuromodulatory mechanism involved in the crotalphine analgesic effect."

11/01/2016 - "Likewise, crotalphine acted on peptidergic TRPA1-expressing nerve endings ex vivo as demonstrated by suppression of calcitonin gene-related peptide release from the trachea and in vivo by inhibition of chemically induced and inflammatory hypersensitivity in mice. "
11/15/2023 - "Next, we showed that crotalphine blocked hypersensitivity and significantly decreased the concentration of IL-1ɑ, IL-1β, IL-6, IL-10, IL-18, TNF-ɑ, MIP-1ɑ and MIP-2 induced by intrathecal injection of exogenous Wnt-3a agonist. "