HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

4- benzyloxy- 3,5- dimethoxy- N- (1- (dimethylaminocyclopently)methyl)benzamide

Glycine Agents

Also Known As:

ORG25543

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Alamein, Claudia: 1 article (01/2022)
2.	Christie, MacDonald J: 1 article (01/2022)
3.	Evans, Sally: 1 article (01/2022)
4.	Gillis, Alexander: 1 article (01/2022)
5.	Mohammadi, Sarasa A: 1 article (01/2022)
6.	Mostyn, Shannon N: 1 article (01/2022)
7.	Peiser-Oliver, Julian: 1 article (01/2022)
8.	Rawling, Tristan: 1 article (01/2022)
9.	Shimmon, Susan: 1 article (01/2022)
10.	Vandenberg, Robert J: 1 article (01/2022)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 08/01/2008 - "In this study, we demonstrated that i.v. or intrathecal administration of GlyT1 inhibitors, cis-N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl methyl)amino methylcarboxylic acid (ORG25935) or sarcosine, and GlyT2 inhibitors, 4-benzyloxy-3,5-dimethoxy-N-[1-(dimethylaminocyclopently)-methyl]benzamide (ORG25543) and (O-[(2-benzyloxyphenyl-3-fluorophenyl)methyl]-L-serine) (ALX1393), or knockdown of spinal GlyTs by small interfering RNA of GlyTs mRNA produced a profound antiallodynia effect in a partial peripheral nerve ligation model and other neuropathic pain models in mice. "
2.	Pain (Aches) 01/01/2021 - "O-[(2-benzyloxyphenyl-3-fluorophenyl)methyl]-l-serine (ALX1393) and N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide (ORG25543) are two selective GlyT2 inhibitors with nanomolar affinity for the transporter and analgesic effects in pain animal models, although with deficiencies which preclude further clinical development. "
3.	Hyperalgesia 01/01/2022 - "These results contrasted markedly with ORG25543, which reached less than 50% reduction in allodynia score only at the lethal/near-lethal dose of 50 mg/kg. At this dose, ORG25543 caused maximal side effects on the numerical rating score and severe convulsions. "

Related Drugs and Biologics

1.	Serine (L-Serine)
2.	ALX 1393
3.	benzamide
4.	Small Interfering RNA (siRNA)
5.	Sarcosine (Methylglycine)
6.	Messenger RNA (mRNA)
7.	Acids
8.	N- methyl- N- (6- methoxy- 1- phenyl- 1,2,3,4- tetrahydronaphthalen- 2- ylmethyl)aminomethylcarboxylic acid
9.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Ligation