coronarin D

from Hedychium coronarium; inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis; structure in first source

Also Known As:

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hsieh, Ming-Ju: 4 articles (08/2020 - 12/2017)
2.	Chen, Mu-Kuan: 3 articles (08/2020 - 12/2017)
3.	Chuang, Yi-Ching: 3 articles (08/2020 - 12/2017)
4.	Lin, Chia-Chieh: 3 articles (08/2020 - 12/2017)
5.	Lo, Yu-Sheng: 3 articles (08/2020 - 12/2017)
6.	Chou, Ming-Chih: 2 articles (08/2020 - 04/2019)
7.	Hsi, Yi-Ting: 2 articles (04/2019 - 12/2017)
8.	Aggarwal, Bharat B: 2 articles (11/2018 - 10/2008)
9.	Hsieh, Ming-Yu: 1 article (08/2020)
10.	Chen, Zhongjun: 1 article (02/2020)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2020 - "Coronarin D (CD) is one of the main components of Hedychium coronarium rhizome, which has therapeutic potential by reducing cell proliferation in cancer cells. " 02/01/2020 - "Coronarin D (CD) is one of the primary components of the Hedychium coronarium rhizomes and possesses strong anticancer effects via preventing cell growth in many cancer cells. " 09/01/2018 - "Coronarin D can exert strong anticancer effects through cell growth prevention and cell cycle arrest in many cancer cells. " 12/09/2019 - "The aim of the present study was to determine the anti-cancer properties of Coronarin D in the glioblastoma cell line and further elucidate the underlying molecular mechanisms. "
2.	Hepatocellular Carcinoma (Hepatoma) 09/01/2018 - "In this study, we investigated the molecular mechanism through which coronarin D suppresses cell proliferation and triggers cell death in human hepatocellular carcinoma (HCC) cells. " 09/01/2018 - "Coronarin D induces apoptotic cell death through the JNK pathway in human hepatocellular carcinoma." 04/01/2019 - "Coronarin D (CD) has been confirmed to have anti-inflammatory, anti-bacterial effects, and anti-apoptotic effects in human hepatocellular carcinoma and nasopharyngeal carcinoma. "
3.	Osteosarcoma (Osteogenic Sarcoma) 08/23/2018 - "In this study, we demonstrated that coronarin D, a natural component extracted from the rhizomes of Hedychium coronarium, significantly suppressed the proliferation of osteosarcoma cells. " 08/23/2018 - "Taken together, our findings indicate that coronarin D induces the apoptosis and mitosis arrest in human osteosarcoma cells. " 08/23/2018 - "We hypothesize that functional evaluation of JNK may produce more specific and effective therapies in coronarin D-related trail for treatment of human osteosarcoma." 08/23/2018 - "JNK Inactivation Induces Polyploidy and Drug-Resistance in Coronarin D-Treated Osteosarcoma Cells." 08/23/2018 - "Furthermore, the treatment with coronarin D increased the levels of phosphorylated c-Jun NH2-terminal kinase (JNK) in human osteosarcoma cells. "
4.	Glioblastoma (Glioblastoma Multiforme) 12/09/2019 - "Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line." 12/09/2019 - "The aim of the present study was to determine the anti-cancer properties of Coronarin D in the glioblastoma cell line and further elucidate the underlying molecular mechanisms. " 12/09/2019 - "These findings highlight the antiproliferative activity of Coronarin D against glioblastoma cell line U-251 and provide a basis for further investigation on its antineoplastic activity on brain cancer." 12/09/2019 - "Coronarin D potently suppressed cell viability in glioblastoma U-251 cell line, and also induced G1 arrest by reducing p21 protein and histone H2AX phosphorylation, leading to DNA damage and apoptosis. "
5.	Mouth Neoplasms (Oral Cancer) 04/01/2019 - "Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway." 08/01/2020 - "Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway."

Related Drugs and Biologics

1.	Cyclin B1
2.	p38 Mitogen-Activated Protein Kinases
3.	Genistein
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	NF-kappa B (NF-kB)
6.	Transcription Factors (Transcription Factor)
7.	Quercetin
8.	Proteins (Proteins, Gene)
9.	Phosphotransferases (Kinase)
10.	Histones (Histone)

Related Therapies and Procedures

1.	Therapeutics