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5-fluoropentyl-2-methylmalonic acid

used for imaging apoptosis; structure in first source

Also Known As:

18F-ML-10 compound; 18F-ML10; 2-(5-fluoro-pentyl)-2-methyl-malonic acid; 5-fluoropentyl(methyl)propanedioic acid

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Malonates: 1
        Methylmalonic Acid: 503
        5-fluoropentyl-2-methylmalonic acid: 3

Experts

1.	Mountz, James M: 2 articles (01/2017 - 03/2014)
2.	Ahmed, Rafay: 1 article (01/2017)
3.	Anderson, Carolyn J: 1 article (01/2017)
4.	DeBlasio, Nicole: 1 article (01/2017)
5.	Demirci, Emre: 1 article (01/2017)
6.	Latoche, Joseph: 1 article (01/2017)
7.	Mason, N Scott: 1 article (01/2017)
8.	Ocak, Meltem: 1 article (01/2017)
9.	Radelet, April: 1 article (01/2017)
10.	Drappatz, Jan: 1 article (03/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "We investigated 2-(5-fluoro-pentyl)-2-methyl-malonic acid (18F-ML-10) positron emission tomography (PET) imaging of apoptosis posttherapy to determine optimal timing for predicting chemotherapy response in a mouse head/neck xenograft cancer model. " 06/01/2013 - "68Ga-Cys2-AnxA5, but not 18F-ML10, allowed to visualize the effect of tumor therapy in a statistically significant way." 06/01/2013 - "Tumor uptake of 68Ga-Cys2-AnxA5, but not of 18F-ML10, was statistically significantly higher after therapy as measured with PET/MRI. " 06/01/2013 - "Furthermore, 18F-ML10 and 68Ga-Cys2-AnxA5 were evaluated in a rat model with reperfused liver infarct and a rat model with cerebral infarct as well as in Daudi tumor bearing mice, before and after treatment with cyclophosphamide and/or radiotherapy. "
2.	Glioblastoma (Glioblastoma Multiforme) 03/01/2014 - "The authors present the first use of the novel positron emission tomography (PET) apoptosis tracer (18)F-labeled 2-(5-fluoro-pentyl)-2-methyl-malonic acid ((18)F-ML-10) for early-therapy response assessment of a newly diagnosed glioblastoma multiforme (GBM) patient. "
3.	Cerebral Infarction 06/01/2013 - "The uptake of both 18F-ML10 and 68Ga-Cys2-AnxA5 increased in the apoptotic region surrounding the cerebral infarction and the reperfused liver infarction. " 06/01/2013 - "Furthermore, 18F-ML10 and 68Ga-Cys2-AnxA5 were evaluated in a rat model with reperfused liver infarct and a rat model with cerebral infarct as well as in Daudi tumor bearing mice, before and after treatment with cyclophosphamide and/or radiotherapy. "
4.	Hepatic Infarction 06/01/2013 - "The uptake of both 18F-ML10 and 68Ga-Cys2-AnxA5 increased in the apoptotic region surrounding the cerebral infarction and the reperfused liver infarction. " 06/01/2013 - "Furthermore, 18F-ML10 and 68Ga-Cys2-AnxA5 were evaluated in a rat model with reperfused liver infarct and a rat model with cerebral infarct as well as in Daudi tumor bearing mice, before and after treatment with cyclophosphamide and/or radiotherapy. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1.	Secondary Prevention
2.	Therapeutics
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)