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IPI 269609

inhibits Hedgehog signaling; inhibits tumor initiation and metastasis in pancreatic cancer; structure in first source

Also Known As:

IPI-269609; IPI269609

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Alvarez, Hector: 1 article (09/2008)
2.	Bedja, Djahida: 1 article (09/2008)
3.	Bisht, Savita: 1 article (09/2008)
4.	Feldmann, Georg: 1 article (09/2008)
5.	Fendrich, Volker: 1 article (09/2008)
6.	Gabrielson, Kathleen L: 1 article (09/2008)
7.	Habbe, Nils: 1 article (09/2008)
8.	Karikari, Collins: 1 article (09/2008)
9.	Koorstra, Jan-Bart M: 1 article (09/2008)
10.	Maitra, Anirban: 1 article (09/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "Selective ex vivo depletion of aldehyde dehydrogenase-bright cells with IPI-269609 was accompanied by significant reduction in tumor engraftment rates in athymic mice. " 09/01/2008 - "Single-agent IPI-269609 profoundly inhibited systemic metastases in orthotopic xenografts established from human pancreatic cancer cell lines, although Hedgehog blockade had minimal effect on primary tumor volume. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 09/01/2008 - "Single-agent IPI-269609 profoundly inhibited systemic metastases in orthotopic xenografts established from human pancreatic cancer cell lines, although Hedgehog blockade had minimal effect on primary tumor volume. " 09/01/2008 - "In vitro treatment of pancreatic cancer cell lines with IPI-269609 resembled effects observed using cyclopamine (i.e., Gli-responsive reporter knockdown, down-regulation of the Hedgehog target genes Gli1 and Ptch, as well as abrogation of cell migration and colony formation in soft agar). "
3.	Neoplasm Metastasis (Metastasis) 09/01/2008 - "Single-agent IPI-269609 profoundly inhibited systemic metastases in orthotopic xenografts established from human pancreatic cancer cell lines, although Hedgehog blockade had minimal effect on primary tumor volume. "

Related Drugs and Biologics

1.	Aldehyde Dehydrogenase
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