2- cyclopentyl- 4- (5- phenyl- 1H- pyrrolo(2,3- b)pyridin- 3- yl)- benzoic acid

a serum-glucocorticoid regulated kinase-1 inhibitor; structure in first source

Also Known As:

GSK 650394; GSK-650394; GSK650394

Networked: 19 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid: 19
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid: 19
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid: 19

Experts

1.	Chen, Yuhua: 2 articles (04/2018 - 10/2017)
2.	Dai, Yibei: 2 articles (04/2018 - 10/2017)
3.	Duan, Xiuzhi: 2 articles (04/2018 - 10/2017)
4.	Li, Xiang: 2 articles (04/2018 - 10/2017)
5.	Liao, Zhaoping: 2 articles (04/2018 - 10/2017)
6.	Liu, Chunhua: 2 articles (04/2018 - 10/2017)
7.	Liu, Weiwei: 2 articles (04/2018 - 10/2017)
8.	Liu, Zhenping: 2 articles (04/2018 - 10/2017)
9.	Tao, Zhihua: 2 articles (04/2018 - 10/2017)
10.	Wang, Xuchu: 2 articles (04/2018 - 10/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "GSK650394, a SGK1 inhibitor, has been proved to be effective in impeding tumor growth in vitro. " 01/01/2017 - "In this study, we developed a novel analog of GSK650394, and evaluated its effects on CRC cells and tumor growth both in vitro and in vivo. " 12/01/2022 - "Further cell-based assays demonstrate that GSK650394 efficiently suppresses the proliferation of both cancer cells and Aspergillus fumigatus. " 01/01/2019 - "We further demonstrate that combined use of GSK650394 and melatonin yields substantial regression of cervical tumors in vivo. "
2.	Bone Resorption 01/01/2022 - "The purpose of present study was to explore the underlying mechanisms of GSK 650394 (GSK) on inhibiting formation and activation of OC and bone resorption in vitro and in vivo. "
3.	Ischemia 04/01/2023 - "In groups that received the SGK1 inhibitor, the heart was perfused with the SGK1 inhibitor GSK650394, 5 min before induction of ischemia. " 03/01/2023 - "In 2 groups, GSK650394 was infused 5 min before ischemia induction. " 01/01/2021 - "Ischemia-reperfusion increased (+34%, p < 0.05) and GSK650394 decreased (-25%, p < 0.05) the Ki in the ischemic-reperfused cortex. " 03/01/2023 - "This research aimed to investigate the effect of coadministration of gallic acid and the GSK650394 (as SGK1 gene inhibitor) on the ischemic complications of a rat model of cardiac ischemia/reperfusion (I/R) injury. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2021 - "After transient middle cerebral artery occlusion (MCAO), an SGK1 inhibitor GSK650394, or vehicle was administered into the lateral ventricle of rats. " 01/01/2016 - "Contrary to our expectation, infarct volume by stroke decreased significantly when SGK inhibitor, gsk650394, or EMD638683, was administrated 30 min before middle cerebral artery occlusion under normal and diabetic conditions. "
5.	Prostatic Neoplasms (Prostate Cancer) 04/02/2018 - "We investigated the cellular responses to GSK650394 treatment and SGK1 silencing (or overexpression) in human prostate cancer (PCa) cell lines and PC3 xenografts by wound healing assay, migration and invasion assay, western blotting, immunofluorescence and immunohistochemistry. " 10/10/2017 - "We investigated the cellular responses to GSK650394 treatment and SGK1 silencing (or overexpression) in human prostate cancer (PCa) cell lines and PC3 xenografts by flow cytometry, western blotting, immunofluorescence, transmission electron microscopy and immunohistochemistry. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphotransferases (Kinase)
3.	Melatonin
4.	Glucocorticoids
5.	Gallic Acid
6.	Etoposide (VP 16)
7.	Bacterial DNA
8.	EMD 638683
9.	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- one
10.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde

Related Therapies and Procedures

1.	Spinal Injections