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R 147176

a renoprotective agent that inhibits both oxidative stress and advanced glycation; structure in first source

Also Known As:

R-147176; R147176

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiazolidinediones: 2250
        R 147176: 2
    - Imidazoles: 150
      - R 147176: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidinediones: 2250
      - R 147176: 2

Experts

1.	Dan, Takashi: 2 articles (10/2009 - 10/2008)
2.	Miyata, Toshio: 2 articles (10/2009 - 10/2008)
3.	van Ypersele de Strihou, Charles: 2 articles (10/2009 - 10/2008)
4.	Nagata, Eiichiro: 1 article (10/2009)
5.	Takagi, Shigeharu: 1 article (10/2009)
6.	Takizawa, Shunya: 1 article (10/2009)
7.	Uesugi, Tsuyoshi: 1 article (10/2009)
8.	Ito, Sadayoshi: 1 article (10/2008)
9.	Izuhara, Yuko: 1 article (10/2008)
10.	Koike, Hiroyuki: 1 article (10/2008)

Related Diseases

1.	Stroke (Strokes) 10/01/2009 - "These findings suggest potential usefulness of R-147176 as a pharmacological tool to investigate the ARBs' protective effect in experimental stroke and open new therapeutic avenues." 10/01/2009 - "To obtain a pharmacological tool to dissect the mechanisms of ARBs' protective benefits in experimental stroke, we synthesized a novel ARB-derivative, R-147176, which is 6,700 times less potent than olmesartan in AT(1)-binding inhibition and therefore has a minimal antihypertensive effect, but retains marked inhibitory effects on oxidative stress and advanced glycation. "
2.	Brain Infarction 10/01/2009 - "We evaluated the effect of R-147176 (10-30 mg/kg per day), administered orally or intravenously, on brain infarct volume in transient thread occlusion and photothrombotic models in rats. "
3.	Kidney Diseases (Kidney Disease) 10/01/2008 - "R-147176 opens new avenues in the treatment of cardiovascular and kidney diseases."
4.	Infarction (Infarctions) 10/01/2009 - "R-147176 significantly reduced infarct volume, without influence on blood pressure, in both models. "

Related Drugs and Biologics

1.	Antihypertensive Agents (Antihypertensives)
2.	olmesartan