(Z)- 2- (4'- methoxy- 3'- aminophenyl)- 1- (3,4,5- trifluorophenyl)ethene

trifluorinated amino-combretastatin analog; a potent inhibitor of tubulin assembly and cytotoxic against selected human cancer cell lines; structure in first source

Also Known As:

MAPTFPE cpd

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Bibenzyls: 16
        (Z)-2-(4'-methoxy-3'-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene: 1
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - (Z)-2-(4'-methoxy-3'-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene: 1

Experts

1.	Chaplin, David J: 1 article (09/2008)
2.	Hadimani, Mallinath B: 1 article (09/2008)
3.	Hall, John J: 1 article (09/2008)
4.	Jelinek, Christopher J: 1 article (09/2008)
5.	Kumar, G D Kishore: 1 article (09/2008)
6.	Pettit, George R: 1 article (09/2008)
7.	Pinney, Kevin G: 1 article (09/2008)
8.	Sriram, Madhavi: 1 article (09/2008)
9.	Strecker, Tracy E: 1 article (09/2008)
10.	Tidmore, Justin K: 1 article (09/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2008 - "A new trifluorinated amino-combretastatin analogue, (Z)-2-(4'-methoxy-3'-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC(50)=2.9 microM), and cytotoxic against selected human cancer cell lines. "

Related Drugs and Biologics

1.	Tubulin
2.	combretastatin