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deficiency Von willebrand factor

Also Known As:

Von willebrand factor, deficiency

Networked: 22 relevant articles (1 outcomes, 3 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Hereditary Hemorrhagic Telangiectasia
3.	Hemophilia A (Haemophilia)
4.	von Willebrand Diseases (von Willebrand's Disease)
5.	Angiodysplasia

Experts

1.	De Meyer, Simon F: 1 article (11/2018)
2.	Deckmyn, Hans: 1 article (11/2018)
3.	Desender, Linda: 1 article (11/2018)
4.	Martinod, Kimberly: 1 article (11/2018)
5.	Portier, Irina: 1 article (11/2018)
6.	Vandeputte, Nele: 1 article (11/2018)
7.	Vanhoorelbeke, Karen: 1 article (11/2018)
8.	Fradkov, Elena: 1 article (06/2017)
9.	Gurvits, Grigoriy E: 1 article (06/2017)
10.	Anze, Grace: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to deficiency Von willebrand factor:

1.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 08/01/1990 - "We conclude that desmopressin may be useful in the management of bleeding in patients with hereditary hemorrhagic telangiectasia with or without von Willebrand factor deficiency." 05/01/2001 - "The authors began to use 1-desamino-8-D-arginine vasopressin (DDAVP) Desmopressin Acetate routinely in their facelift patients who had a relatively high risk of bleeding, either from Von Willebrand factor deficiency, platelet dysfunction, aspirin intake, or ease of ecchymosis. "
2.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/31/1977 - "The results of the present study seem to support the view that a platelet defect, induced by aspirin, causes a significant lengthening of bleeding time only in the cases with severe von Willebrand factor deficiency." 01/01/1997 - "Thus, aspirin is contraindicated in ET patients with a bleeding history or a very high platelet count (> 1500 x 10(9)/L) leading to the acquisition of von Willebrand factor deficiency. " 02/12/1991 - "Evaluation of the buccal bleeding time and platelet glass bead retention as assays of hemostasis in the dog: the effects of acetylsalicylic acid, warfarin and von Willebrand factor deficiency." 05/01/2001 - "The authors began to use 1-desamino-8-D-arginine vasopressin (DDAVP) Desmopressin Acetate routinely in their facelift patients who had a relatively high risk of bleeding, either from Von Willebrand factor deficiency, platelet dysfunction, aspirin intake, or ease of ecchymosis. "
3.	Blood Coagulation Factors (Coagulation Factor)IBA 01/23/1993 - "The sera of patients with hemophilia and von Willebrand factor deficiency, collected during clinical trials with virus-inactivated coagulation factor preparations, were retrospectively screened for the presence of antibodies against hepatitis C virus (HCV). " 09/01/2003 - "However, there are several unique hemostatic derangements associated with lymphoproliferative disorders that express paraproteins and these are the subject of this article (eg, inhibition of fibrin polymerization, qualitative platelet dysfunction, acquired von Willebrand factor deficiency, heparin-like circulating anticoagulants, light chain amyloid associated hemostatic disorders, acquired coagulation factor deficiencies, and acquired hypercoagulable states). "
4.	AntibodiesIBA 01/23/1993 - "The sera of patients with hemophilia and von Willebrand factor deficiency, collected during clinical trials with virus-inactivated coagulation factor preparations, were retrospectively screened for the presence of antibodies against hepatitis C virus (HCV). "
5.	multimerinIBA 10/01/1998 - "Studies of multimerin in patients with von Willebrand disease and platelet von Willebrand factor deficiency."
6.	von Willebrand FactorIBA 01/01/1990 - "von Willebrand factor is present in the vascular endothelium from normal dogs and from Doberman pinscher dogs with a plasma von Willebrand factor deficiency." 07/01/1999 - "Reduction of the platelet count < 1,000 x 10(9)/L significantly restores the von Willebrand factor deficiency with the reappearance of the intermediate and some of the large von Willebrand factor multimers and the disappearance of the bleeding tendency, but the thrombotic tendency persists as long as platelet counts are above the upper limit of normal. " 07/01/1999 - "An increasing platelet count in thrombocythemia to above 1,000 x 10(9)/L is accompanied by the acquisition of a von Willebrand factor deficiency due to the loss of intermediate and large von Willebrand factor multimers. " 09/01/1996 - "The laboratory features of acquired von Willebrand defect (AvWD) in myeloproliferative disorders (MPD) are characterized by a very high platelet count, a normal or prolonged bleeding time, a normal factor VIII and von Willebrand factor (vWF) antigen level, but a decreased vWF-ristocetine cofactor activity and collagen binding activity with a decrease or absence of large vWF-multimers simulating a type II von Willebrand factor deficiency. "
7.	Factor VIII (Coagulation Factor VIII)IBA 06/01/1996 - "Acquired von Willebrand factor deficiency during high-dose infusion of recombinant factor VIII." 05/01/2013 - "As a result of von Willebrand factor deficiency or abnormality, levels of factor VIII, the protein deficient in hemophilia A, may be variably reduced. " 09/01/1996 - "The laboratory features of acquired von Willebrand defect (AvWD) in myeloproliferative disorders (MPD) are characterized by a very high platelet count, a normal or prolonged bleeding time, a normal factor VIII and von Willebrand factor (vWF) antigen level, but a decreased vWF-ristocetine cofactor activity and collagen binding activity with a decrease or absence of large vWF-multimers simulating a type II von Willebrand factor deficiency. "
8.	FibrinIBA 08/01/2015 - "Hyaluronidase 2-deficient mice had increased markers of endothelial damage and microvascular fibrin deposition, without renal failure, accumulation of ultra-large multimers of von Willebrand factor, deficiency of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13), or hypertension. " 09/01/2003 - "However, there are several unique hemostatic derangements associated with lymphoproliferative disorders that express paraproteins and these are the subject of this article (eg, inhibition of fibrin polymerization, qualitative platelet dysfunction, acquired von Willebrand factor deficiency, heparin-like circulating anticoagulants, light chain amyloid associated hemostatic disorders, acquired coagulation factor deficiencies, and acquired hypercoagulable states). "
9.	Metalloproteases (Metalloproteinases)IBA 08/01/2015 - "Hyaluronidase 2-deficient mice had increased markers of endothelial damage and microvascular fibrin deposition, without renal failure, accumulation of ultra-large multimers of von Willebrand factor, deficiency of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13), or hypertension. "
10.	ThrombospondinsIBA 08/01/2015 - "Hyaluronidase 2-deficient mice had increased markers of endothelial damage and microvascular fibrin deposition, without renal failure, accumulation of ultra-large multimers of von Willebrand factor, deficiency of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13), or hypertension. "

Therapies and Procedures

1.	Heart-Assist Devices 01/01/2015 - "A new spin on acquired von Willebrand factor deficiency during continuous-flow left ventricular assist device support." 06/14/2017 - "A significant number of left ventricular assist devices (LVAD) recipients may experience recurrent gastrointestinal hemorrhage, mainly due to combination of antiplatelet and vitamin K antagonist therapy, activation of fibrinolytic pathway, acquired von Willebrand factor deficiency, and tendency to develop small intestinal angiodysplasias due to increased rotary speed of the pump. "
2.	Prostheses and Implants (Prosthesis) 05/16/2023 - "Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure-A Narrative Review."
3.	Lung Transplantation 12/01/2015 - "Von Willebrand Factor Deficiency Corrected by Lung Transplantation."
4.	Rhytidoplasty (Facelift) 05/01/2001 - "The authors began to use 1-desamino-8-D-arginine vasopressin (DDAVP) Desmopressin Acetate routinely in their facelift patients who had a relatively high risk of bleeding, either from Von Willebrand factor deficiency, platelet dysfunction, aspirin intake, or ease of ecchymosis. "
5.	Therapeutics 06/14/2017 - "A significant number of left ventricular assist devices (LVAD) recipients may experience recurrent gastrointestinal hemorrhage, mainly due to combination of antiplatelet and vitamin K antagonist therapy, activation of fibrinolytic pathway, acquired von Willebrand factor deficiency, and tendency to develop small intestinal angiodysplasias due to increased rotary speed of the pump. "