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Amyotrophic lateral sclerosis 1

While mostly a sporadic disease, approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial. ALS I can exhibit autosomal dominant or recessive inheritance. Patients have reduced levels of superoxide dismutase-1 (SOD1). Germline mutations in the SOD1 gene are associated with developing ALS1; mutations in the ANG, NEFH, PRPH, and DCTN1 are associated with susceptibility. OMIM: 105400
Also Known As:
Amyotrophic Lateral Sclerosis, Autosomal Dominant; Amyotrophic Lateral Sclerosis, Familial; Amyotrophic Lateral Sclerosis, Sporadic
Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Stroke (Strokes)
3. Substance-Related Disorders (Drug Abuse)
4. Spinal Injuries (Spinal Injury)
5. Schizophrenia (Dementia Praecox)

Experts

1. Ang, Ching-Seng: 1 article (01/2020)
2. Hatters, Danny M: 1 article (01/2020)
3. Lilley, Jordan D: 1 article (01/2020)
4. Radwan, Mona: 1 article (01/2020)
5. Reid, Gavin E: 1 article (01/2020)
6. Baumann, Ulrich: 1 article (03/2017)
7. Bischof, Joachim: 1 article (03/2017)
8. Brunstein, Elena: 1 article (03/2017)
9. Bührmann, Mike: 1 article (03/2017)
10. Halekotte, Jakob: 1 article (03/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amyotrophic lateral sclerosis 1:
1. UbiquitinIBA
2. Minocycline (Cyclops)FDA LinkGeneric
3. Superoxide Dismutase-1IBA
4. ZincIBA
5. CopperIBA
6. Alanine (L-Alanine)FDA Link
7. Valine (L-Valine)FDA Link
8. Proteins (Proteins, Gene)FDA Link
9. Protein Kinases (Protein Kinase)IBA
10. Glycine (Aminoacetic Acid)FDA LinkGeneric

Therapies and Procedures

1. Intravenous Administration