Steroid 21-Hydroxylase

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Also Known As:

21 Hydroxylase; 21-Hydroxylase; Steroid 21 Monooxygenase; Cytochrome P-450 21-Hydroxylase; Cytochrome P-450 c21; Cytochrome P-450(c-21); Cytochrome P450c21; Progesterone 21-Hydroxylase; Steroid-21-Hydroxylase; Cytochrome P 450 21 Hydroxylase; Cytochrome P 450 CYP21; Cytochrome P 450 c21; P-450 c21, Cytochrome; Progesterone 21 Hydroxylase; Steroid 21 Hydroxylase; Cytochrome P-450 CYP21; Steroid 21-Monooxygenase; Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Steroid 21-Hydroxylase: 743
        Cytochrome P450 Family 21: 4
        Steroid 21-Hydroxylase: 743
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Steroid Hydroxylases: 11
      - Steroid 21-Hydroxylase: 743
    - Cytochrome P450 Family 21: 4
      - Steroid 21-Hydroxylase: 743
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Steroid 21-Hydroxylase: 743
        Cytochrome P450 Family 21: 4
        Steroid 21-Hydroxylase: 743

rat Cyp21a1 protein

Bio-Agent Context: Research Results