Staurosporine

An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

Also Known As:

8,12- Epoxy- 1H,8H- 2,7b,12a- triazadibenzo(a,g)cyclonona(cde)trinden- 1- one, 2,3,9,10,11,12- hexahydro- 9- methoxy- 8- methyl- 10- (methylamino)- , (8alpha,9beta,10beta,12alpha)-(+)-

Pharmalogical Action Categories:

Enzyme Inhibitors

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Staurosporine: 958
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Staurosporine: 958
      - Carbazoles: 32
        Staurosporine: 958
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Staurosporine: 958
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - Staurosporine: 958

7-oxo-3,8,9-trihydroxystaurosporine

Bio-Agent Context: Research Results