Iron(III)-salophene

is a potent growth-suppressing agent in vitro for cell lines derived from ovarian cancer and a potential therapeutic drug to treat such tumors in vivo; structure in first source

Also Known As:

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Brard, Laurent: 3 articles (04/2011 - 05/2008)
2.	Kim, Kyu Kwang: 3 articles (04/2011 - 05/2008)
3.	Lange, Thilo S: 3 articles (04/2011 - 05/2008)
4.	Singh, Rakesh K: 3 articles (04/2011 - 05/2008)
5.	Strongin, Robert M: 3 articles (04/2011 - 05/2008)
6.	Moore, Richard G: 1 article (04/2011)
7.	Gust, Ronald: 1 article (11/2010)
8.	Hille, Annegret: 1 article (11/2010)
9.	Alptürk, Onur: 1 article (09/2009)
10.	Luisi, Brian S: 1 article (09/2009)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 09/21/2009 - "Apoptotic and chemotherapeutic properties of iron (III)-salophene in an ovarian cancer animal model." 05/28/2008 - "In this pioneer study to the biological activity of organometallic compound Iron(III)-salophene (Fe-SP) the specific effects of Fe-SP on viability, morphology, proliferation, and cell-cycle progression on platinum-resistant ovarian cancer cell lines were investigated. " 05/28/2008 - "Iron(III)-salophene: an organometallic compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells."
2.	Neuroblastoma 04/29/2011 - "The objective of the present study was to investigate the specific effects of Iron(III)-salophene (Fe-SP) on viability, morphology, proliferation, cell cycle progression, ROS generation and pro-apoptotic MAPK activation in neuroblastoma (NB) cells. " 04/29/2011 - "Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation."
3.	Carcinoma (Carcinomatosis) 11/01/2010 - "We synthesized methoxy-substituted iron(III)-salophene complexes ([Fe(III)(OMe-salophene)Cl] with salophene = N,N'-bis(salicylidene)-1,2-phenylenediamine) and analyzed their biological activity in MCF-7 and MDA-MB-231 breast cancer as well as in HT-29 colon carcinoma cells. "
4.	Breast Neoplasms (Breast Cancer) 11/01/2010 - "We synthesized methoxy-substituted iron(III)-salophene complexes ([Fe(III)(OMe-salophene)Cl] with salophene = N,N'-bis(salicylidene)-1,2-phenylenediamine) and analyzed their biological activity in MCF-7 and MDA-MB-231 breast cancer as well as in HT-29 colon carcinoma cells. "

Related Drugs and Biologics

1.	Platinum
2.	Organometallic Compounds