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argyrin A

a proteosome inhibitor that has antineoplastic activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - argyrin A: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - argyrin A: 2

Experts

1.	Hao, Pei: 1 article (04/2013)
2.	Li, Chunyan: 1 article (04/2013)
3.	Li, Xuan: 1 article (04/2013)
4.	Li, Yixue: 1 article (04/2013)
5.	Ma, Chenchen: 1 article (04/2013)
6.	Yu, Shuhao: 1 article (04/2013)
7.	Yu, Yang: 1 article (04/2013)
8.	Zheng, Lulu: 1 article (04/2013)
9.	McConkey, David J: 1 article (07/2008)

Related Diseases

1.

Neoplasms (Cancer)

04/10/2013 - "In contrast, Argyrin A had influence on cell cycle, and was involved in DNA damage repair at the same time, showing that Argyrin A was a more suitable drug for anti-cancer treatment. "
04/10/2013 - "We applied our methods to two drug candidates, Argyrin A and Bortezomib, both with anti-cancer activities. "
07/08/2008 - "In this issue of Cancer Cell, Nickeleit et al. (2008) identify a new proteasome inhibitor, argyrin A, and show that it induces apoptosis and inhibits angiogenesis via p27-dependent mechanisms. "

Related Drugs and Biologics

1.	Proteasome Inhibitors
2.	Bortezomib (Velcade)