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1- (2- hydroxy- 2- methylpropyl)- N- (5- (7- methoxyquinolin- 4- yloxy)pyridin- 2- yl)- 5- methyl- 3- oxo- 2- phenyl- 2,3- dihydro- 1H- pyrazole- 4- carboxamide

a c-met inhibitor; structure in first source

Also Known As:

AMG 458; AMG-458; AMG458

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide: 2
  - Pyridines: 88
    - Aminopyridines: 77
      - 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide: 2

Experts

1.	Dicker, Adam P: 1 article (11/2012)
2.	Du, Ruihong: 1 article (11/2012)
3.	Li, Bo: 1 article (11/2012)
4.	Lu, Bo: 1 article (11/2012)
5.	Sun, Yunguang: 1 article (11/2012)
6.	Torossian, Artour: 1 article (11/2012)
7.	Albrecht, Brian K: 1 article (11/2008)
8.	Boezio, Alessandro A: 1 article (11/2008)
9.	Colletti, Adria E: 1 article (11/2008)
10.	Harmange, Jean Christophe: 1 article (11/2008)

Related Diseases

1.

Neoplasms (Cancer)

11/15/2012 - "AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c-Met and p-Met in NSCLC tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor."
11/01/2008 - "AMG 458 {1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide} is a potent, selective inhibitor of c-Met, a receptor tyrosine kinase that is often deregulated in cancer. "

Related Drugs and Biologics

1.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
2.	pyrazole

Related Therapies and Procedures

1.	Therapeutics