HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

9- piperazin- 1- ylpyrrolo(2,1- b)benzothiazepine

a potential antipsychotic with very low liability to induce side-effects

Also Known As:

ST2472

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiepins
    - Thiazepines: 6
      - 9-piperazin-1-ylpyrrolo(2,1-b)benzothiazepine: 3

Experts

1.	Borsini, Franco: 3 articles (10/2008 - 05/2008)
2.	Carminati, Paolo: 2 articles (09/2008 - 05/2008)
3.	Ghirardi, Orlando: 2 articles (09/2008 - 05/2008)
4.	Amato, Davide: 1 article (10/2008)
5.	Nencini, Paolo: 1 article (10/2008)
6.	Stasi, Maria Antonietta: 1 article (10/2008)
7.	Caprioli, Antonio: 1 article (09/2008)
8.	Coccurello, Roberto: 1 article (09/2008)
9.	Conti, Roberto: 1 article (09/2008)
10.	Moles, Anna: 1 article (09/2008)

Related Diseases

1.	Polydipsia 10/01/2008 - "The oral effects of haloperidol, olanzapine, clozapine, and ST2472 on QNP-induced polydipsia were analyzed in the following two schedules. " 10/01/2008 - "In the preventive schedule, haloperidol (0.2, 0.4, and 0.8 mg/kg), olanzapine (1.5, 3, and 6 mg/kg), ST2472 (1 and 2 mg/kg), and clomipramine (5, 10, and 20 mg/kg) were given in combination with quinpirole from day 1 to day 5. In the reversal schedule, rats showing quinpirole-induced polydipsia on the third day received haloperidol (0.4 mg/kg), olanzapine (1.5 and 3 mg/kg), clozapine (10, 20, and 40 mg/kg), ST2472 (1, 2, 5, and 10 mg/kg), and clomipramine (5, 10, and 20 mg/kg) before quinpirole on days 4 and 5. Haloperidol both prevented and reversed quinpirole-induced polydipsia, whereas olanzapine and ST2472 only reversed it. "
2.	Weight Gain 09/01/2008 - "A mouse model of atypical antipsychotic-associated adverse effects was used to compare the liability to induce weight gain, food intake, and metabolic alterations after chronic olanzapine (OL; LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5] benzodiazepine) and ST2472 (ST; 9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine) administration. " 09/01/2008 - "Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice."
3.	Hyperphagia (Overeating) 09/01/2008 - "Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice."
4.	Catalepsy 05/01/2008 - "This finding, together with the fact that ST2472 does not induce catalepsy in rodents at up to 100 mg/kg p.o., indicates that ST2472 has very low liability to induce extrapyramidal side-effects. "

Related Drugs and Biologics

1.	Olanzapine (Zyprexa)
2.	Quinpirole
3.	Antipsychotic Agents (Antipsychotics)
4.	Haloperidol (Haldol)
5.	Clozapine (Clozaril)
6.	Clomipramine (Anafranil)
7.	Benzodiazepines