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7- (7- amino- 7- methyl- 5- azaspiro(2.4)heptan- 5- yl)- 6- fluoro- 1- (2- fluoro- 1- cyclopropyl)- 1,4- dihydro- 8- methoxy- 4- oxo- 3- quinolinecarboxylic acid

has antibacterial activity

Also Known As:

DC 159a; DC-159a; DC159a

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - 7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - 7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        Fluoroquinolones: 5348
        7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid: 5

Experts

1.	Nakajima, Chie: 2 articles (01/2019 - 09/2016)
2.	Suzuki, Yasuhiko: 2 articles (01/2019 - 09/2016)
3.	Yamaguchi, Tomoyuki: 2 articles (01/2019 - 09/2016)
4.	Koide, Kentaro: 1 article (01/2019)
5.	Kongsoi, Siriporn: 1 article (01/2019)
6.	Ouchi, Yuki: 1 article (01/2019)
7.	Yokoyama, Kazumasa: 1 article (09/2016)
8.	Ahmad, Zahoor: 1 article (04/2011)
9.	Grosset, Jacques H: 1 article (04/2011)
10.	Mdluli, Khisimuzi E: 1 article (04/2011)

Related Diseases

1.	Leprosy (Hansen's Disease) 09/01/2016 - "To gather data that can support highly effective fluoroquinolones as candidates for new remedies for leprosy treatment, we conducted in vitro assays to assess and compare the inhibitory activities of DC-159a and two fluoroquinolones that are already known to be more effective against M. "
2.	Infections 10/01/2008 - "The excellent in vitro activity of DC-159a demonstrates its potential for use in the treatment of infections due to mycoplasmas and ureaplasmas." 01/01/2008 - "The bactericidal activity of DC-159a in a murine muscle infection model was revealed to be superior to that of moxifloxacin. "
3.	Community-Acquired Infections 01/01/2008 - "DC-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended activity against gram-positive pathogens, especially streptococci and staphylococci from patients with community-acquired infections. "
4.	Tuberculosis (Tuberculoses) 04/01/2011 - "Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis." 04/01/2011 - "These results warrant further preclinical evaluation of DC-159a in selected drug combinations against drug-susceptible and fluoroquinolone-resistant tuberculosis."
5.	Salmonella Infections (Salmonellosis) 01/01/2019 - "Therefore, DC-159a can be suggested as an antibiotic candidate for treating salmonellosis caused by quinolone-resistant S. "

Related Drugs and Biologics

1.	Fluoroquinolones
2.	Quinolones
3.	Drug Combinations
4.	Anti-Bacterial Agents (Antibiotics)
5.	Moxifloxacin (Avelox)