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2- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(2- hydroxyethyl)amino)ethan- 1- ol

has antineoplastic activity; structure in first source

Also Known As:

CK 0402; CK-0402; CK0402

Networked: 4 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - 2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol: 4
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Sulfides: 1062
        2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol: 4
- Sulfur Compounds: 278
  - Hydrogen Sulfide: 2764
    - Sulfides: 1062
      - 2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfides: 1062
    - 2-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(2-hydroxyethyl)amino)ethan-1-ol: 4

Experts

1.	Kwon, Chul-Hoon: 3 articles (01/2016 - 04/2008)
2.	Chen, Kuen-Yuan: 2 articles (01/2016 - 05/2010)
3.	Chen, Kun-Ming: 2 articles (01/2016 - 05/2010)
4.	Sun, Yuan-Wan: 2 articles (01/2016 - 05/2010)
5.	Niu, Ting-Kuang: 1 article (05/2010)
6.	Yang, Jin-Ming: 1 article (05/2010)
7.	Kang, Hyerim: 1 article (04/2008)
8.	Park, Sang-ki: 1 article (04/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 05/01/2010 - "These findings suggest that CK0402 may be effective against the more aggressive and malignant ER(-) and HER2-overexpressing breast cancer. " 05/01/2010 - "In the present study, we tested the effects of CK0402 in a panel of established human breast cancer cells with varying ER and HER2/neu status. " 01/01/2016 - "A previous study by our group reported that CK0402 was effective against numerous breast cancer cell lines, and the combination of CK0402 with herceptin enhanced its activity in HER2(+) SKBR‑3 cells. " 01/01/2016 - "The results showed that CK0403 exerted more potent growth inhibitory activity than CK0402 in all of the breast cancer cell lines except MCF‑7. " 05/01/2010 - "Our results indicate that the combination of CK0402 and Herceptin may be a potential therapeutic option against the more aggressive ER(-) and HER2-overexpressing breast cancer."
2.	Neoplasms (Cancer) 04/01/2008 - "9-anilinoacridine contains a tricyclic and planar aromatic structure that enables DNA intercalation and inhibition of topoisomerase II. Two recently developed sulfide derivatives of 9-anilinoacridines, 2-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino)ethan-1-ol (CK0402) and 3-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(3-hydroxypropyl)amino)propan-1-ol (CK0403), displayed potent cytotoxic activity in multiple cancer cell lines. "

Related Drugs and Biologics

1.	Trastuzumab (Herceptin)
2.	3- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(3- hydroxypropyl)amino)propan- 1- ol
3.	Estrogen Receptors
4.	Sulfides (Thioethers)
5.	Type II DNA Topoisomerases (Topoisomerase II)
6.	DNA (Deoxyribonucleic Acid)
7.	9-anilinoacridine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)