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6,11,12,14,16- pentahydroxyabieta- 5,8,11,13- tetraen- 7- one

an antineoplastic agent isolated from Coleus forshohlii; structure in first source

Also Known As:

coleon C

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Abietanes: 39
        6,11,12,14,16-pentahydroxyabieta-5,8,11,13-tetraen-7-one: 1
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        Abietanes: 39
        6,11,12,14,16-pentahydroxyabieta-5,8,11,13-tetraen-7-one: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Abietanes: 39
      - 6,11,12,14,16-pentahydroxyabieta-5,8,11,13-tetraen-7-one: 1

Experts

1.	Huang, Yongping: 1 article (04/2008)
2.	Li, Changlong: 1 article (04/2008)
3.	Li, Qing: 1 article (04/2008)
4.	Liu, Jianwen: 1 article (04/2008)
5.	Liu, Yanwen: 1 article (04/2008)
6.	Wang, Xiaoming: 1 article (04/2008)
7.	Wu, Hezhen: 1 article (04/2008)
8.	Xing, Xiu: 1 article (04/2008)
9.	Yang, Yanfang: 1 article (04/2008)

Related Diseases

1.	Lewis Lung Carcinoma 04/01/2008 - "In the acute toxicity studies of C57BL/6 mice, LD(50 )of Coleon C was 1496+/-150 mg/kg. In the model of Lewis lung carcinoma, the average tumor weight in groups injected with 80 mg/kg Coleon C decreased by 48.9+/-14.3% compared with that of the control. "
2.	Neoplasms (Cancer) 04/01/2008 - "To our knowledge, this is the first report on the anti-tumor activity of Coleon C both in vitro and in vivo." 04/01/2008 - "These results indicate that Coleon C could effectively inhibit tumor cell proliferation and growth by inducing apoptosis with low toxicity. " 04/01/2008 - "Coleon C (6,11,12,14,16-pentahydroxyabieta-5,8,11,13-tetraen-7-one), extracted from Coleus forskohlii Briq., was investigated for its anti-tumor activity on eight human tumor cell lines (95-D, A375, HeLa, A431, MKN45, BEL7402, LoVo and HL60) and two normal ones (293, L02) by MTT and colony-forming assay in vitro. " 04/01/2008 - "Inhibition of tumor cell proliferation by Coleon C." 04/01/2008 - "In the acute toxicity studies of C57BL/6 mice, LD(50 )of Coleon C was 1496+/-150 mg/kg. In the model of Lewis lung carcinoma, the average tumor weight in groups injected with 80 mg/kg Coleon C decreased by 48.9+/-14.3% compared with that of the control. "