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glycyl-phenylalanyl-glycine

structure in first source

Also Known As:

Gly-Phe-Gly

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - glycyl-phenylalanyl-glycine: 5

Experts

1.	Abe, Yuki: 1 article (03/2016)
2.	Ashida, Shinji: 1 article (03/2016)
3.	Honda, Takeshi: 1 article (03/2016)
4.	Kasuya, Yuji: 1 article (03/2016)
5.	Masuda, Takeshi: 1 article (03/2016)
6.	Miyazaki, Hideki: 1 article (03/2016)
7.	Morita, Koji: 1 article (03/2016)
8.	Naito, Hiroyuki: 1 article (03/2016)
9.	Nakada, Takashi: 1 article (03/2016)
10.	Ogitani, Yusuke: 1 article (03/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2009 - "CM-Dex-PA-Gly-Gly-Phe-Gly-DXR and CM-Dex-PA-Gly-Gly-Ile-Gly-DXR indicated strong antitumor activity, with the comparable pharmacokinetic profile of released DXR in tumor. " 11/01/1995 - "Compared with DXR, CMPul-DXR conjugates bound through Gly-Gly-Phe-Gly and Gly-Phe-Gly-Gly spacers significantly suppressed the tumor growth, while CMPul-DXR conjugate bound through Gly-Gly-Gly-Gly showed less antitumor effect than DXR. " 03/15/2016 - "The exatecan derivatives were covalently connected via a peptidyl spacer (Gly-Gly-Phe-Gly), which is assumed to be stable in circulation, and were cleaved by lysosomal enzymes following ADC internalization into tumor tissue. " 02/01/2008 - "AZ10992 is a novel paclitaxel-carboxymethyl (CM) dextran conjugate via a Gly-Gly-Phe-Gly linker with the molecular weight (MW) of 150 kDa. Our previous studies demonstrated that AZ10992 exerts strong antitumor activity against the human tumor xenografts that are highly refractory to paclitaxel, attributable to passive tumor targeting of released paclitaxel. "
2.	Carcinosarcoma 10/01/1997 - "CMPul-DXR conjugates bound through Gly-Gly-Phe-Gly and Gly-Phe-Gly-Gly spacers were found to be more potent than DXR after a single intravenous injection in rats bearing Walker 256 carcinosarcoma. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Dextrans (Dextran)
3.	AZ 10992
4.	Enzymes
5.	exatecan (DX 8951f)
6.	glycyl-glycyl-glycyl-glycine

Related Therapies and Procedures

1.	Intravenous Injections