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3',4'-dihydroxyflavonol

a neuroprotective agent

Also Known As:

3,3',4'-trihydroxyflavone; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-hydroxy-

Networked: 25 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        3',4'-dihydroxyflavonol: 25
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        3',4'-dihydroxyflavonol: 25

Experts

1.	Woodman, Owen L: 12 articles (01/2018 - 06/2004)
2.	Mogulkoc, Rasim: 4 articles (02/2022 - 07/2016)
3.	Menevse, Esma: 3 articles (02/2022 - 07/2016)
4.	May, Clive N: 3 articles (07/2015 - 06/2004)
5.	Williams, Spencer J: 3 articles (09/2011 - 03/2008)
6.	Dusting, Gregory J: 3 articles (04/2008 - 06/2004)
7.	Baltaci, Abdulkerim Kasım: 2 articles (02/2022 - 02/2017)
8.	Dasdelen, Dervis: 2 articles (02/2022 - 01/2021)
9.	Baltaci, Abdulkerim Kasim: 2 articles (01/2021 - 07/2016)
10.	Ng, Dominic C H: 2 articles (01/2018 - 07/2015)

Related Diseases

1.	Reperfusion Injury 02/01/2022 - "3',4'-Dihydroxyflavonol (DiOHF) prevents DNA damage, lipid peroxidation and inflammation in ovarian ischaemia-reperfusion injury of rats." 07/01/2016 - "The Effect of 3',4'-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury." 01/01/2018 - "Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2." 10/01/2008 - "3',4'-Dihydroxyflavonol (DiOHF) is a cardioprotective flavonol that can decrease ischaemia/reperfusion injury in the heart. " 01/01/2008 - "Previously we have demonstrated that 3',4'-dihydroxyflavonol (DiOHF), a novel synthetic flavonol, protects against ischemia reperfusion injury in both heart and brain. "
2.	Brain Ischemia (Cerebral Ischemia) 02/01/2017 - "In the present study, effects of 3',4'-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. " 07/01/2016 - "The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. " 02/01/2017 - "3',4'-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia." 07/01/2016 - "The Effect of 3',4'-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury." 01/01/2021 - "Increased apoptosis, tumor necrosis factor-α, and DNA damage attenuated by 3',4'-dihydroxyflavonol in rats with brain İschemia-reperfusion."
3.	Thrombosis (Thrombus) 07/01/2013 - "Treatment with quercetin and 3',4'-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo." 01/01/2013 - "Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3',4'-dihydroxyflavonol and quercetin." 07/01/2013 - "In this study we investigate the ability of two structurally related flavonols; quercetin (Que) and 3',4'-dihydroxyflavonol (DiOHF) to inhibit platelet aggregation, platelet granule exocytosis and vessel occlusion in a well characterized mouse model of platelet mediated arterial thrombosis. " 05/01/2014 - "We have recently shown that the naturally occurring flavonol quercetin (Que) or the synthetic flavonol 3',4'-dihydroxyflavonol (DiOHF) inhibits platelet function and delays thrombus formation in healthy mice. " 05/01/2014 - "The flavonols quercetin and 3',4'-dihydroxyflavonol reduce platelet function and delay thrombus formation in a model of type 1 diabetes."
4.	Spermatic Cord Torsion (Testicular Torsion) 01/01/2015 - "The purpose of this study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on oxidative damage and antioxidant system in experimental testicular torsion-detorsion.The"
5.	Inflammation (Inflammations) 02/01/2022 - "This study aimed to determine the effect of 3',4'-Dihydroxyflavonol (DiOHF) on lipid peroxidation, DNA damage and inflammation in ovarian ischaemia (I)-reperfusion (R) injury. " 02/01/2022 - "3',4'-Dihydroxyflavonol (DiOHF) prevents DNA damage, lipid peroxidation and inflammation in ovarian ischaemia-reperfusion injury of rats."

Related Drugs and Biologics

1.	phospholamban
2.	Flavonols
3.	Quercetin
4.	Antioxidants
5.	3-hydroxyflavone
6.	Flavonoids
7.	Mitogen-Activated Protein Kinase Kinases (MEKs)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Staphylococcal Protein A (Protein A)
10.	Drug Combinations

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