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salograviolide A

isolated from Centaurea ainetensis; structure in first source

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - salograviolide A: 3

Experts

1.	Darwiche, Nadine: 3 articles (07/2012 - 04/2008)
2.	Saliba, Najat A: 3 articles (07/2012 - 04/2008)
3.	Ghantous, Akram: 2 articles (07/2012 - 04/2008)
4.	El-Sabban, Marwan: 2 articles (04/2008 - 04/2008)
5.	Gali-Muhtasib, Hala: 2 articles (04/2008 - 04/2008)
6.	Halawi, Racha: 1 article (07/2012)
7.	Saikali, Melody: 1 article (07/2012)
8.	Talhouk, Salma N: 1 article (07/2012)
9.	Dakdouki, Saadah: 1 article (04/2008)
10.	El-Najjar, Nahed: 1 article (04/2008)

Related Diseases

1.	Carcinogenesis 04/01/2008 - "These studies suggest the potential therapeutic effects of Centaurea ainetensis, and its component, Salograviolide A, against epidermal squamous cell carcinogenesis."
2.	Neoplasms (Cancer) 07/09/2012 - "Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolated from Centaurea ainetensis, for their anti-tumor properties. "
3.	Papilloma (Papillomatosis) 04/01/2008 - "At concentrations that were non-cytotoxic to primary keratinocytes, Centaurea ainetensis crude extract and Salograviolide A preferentially inhibited the proliferation of papilloma and squamous cell carcinoma (SCC) cell lines without significantly affecting the growth of normal cells. "
4.	Colonic Neoplasms (Colon Cancer) 04/01/2008 - "ainetensis extract and its bioactive molecule, Salograviolide A, in colon cancer treatment." 04/01/2008 - "Salograviolide A, at non-cytotoxic concentrations to normal human intestinal cells, reduced the growth of colon cancer cell lines. " 04/01/2008 - "Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis." 04/01/2008 - "Further bioassay-guided fractionation of the crude extract resulted in the identification of the bioactive molecule Salograviolide A, a Sesquiterpene Lactone, to which the growth inhibition in colon cancer was linked. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/01/2008 - "At concentrations that were non-cytotoxic to primary keratinocytes, Centaurea ainetensis crude extract and Salograviolide A preferentially inhibited the proliferation of papilloma and squamous cell carcinoma (SCC) cell lines without significantly affecting the growth of normal cells. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Complex Mixtures
3.	Sesquiterpenes
4.	Lactones