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1- (10- ((E)- 3- phenyl- allyl)- 3,10- diaza- bicyclo(4.3.1)dec- 3- yl)propan- 1- one

attenuates nociceptive transmission in animal models of experimental pain; structure in first source

Also Known As:

NS7051

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - 1-(10-((E)-3-phenyl-allyl)-3,10-diaza-bicyclo(4.3.1)dec-3-yl)propan-1-one: 1
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - 1-(10-((E)-3-phenyl-allyl)-3,10-diaza-bicyclo(4.3.1)dec-3-yl)propan-1-one: 1

Experts

1.	Baek, Camilla A E: 1 article (02/2008)
2.	Erichsen, Helle K: 1 article (02/2008)
3.	Munro, Gordon: 1 article (02/2008)
4.	Nielsen, Alexander N: 1 article (02/2008)
5.	Nielsen, Elsebet Ø: 1 article (02/2008)
6.	Peters, Dan: 1 article (02/2008)
7.	Scheel-Kruger, Jørgen: 1 article (02/2008)
8.	Weikop, Pia: 1 article (02/2008)

Related Diseases

1.	Pain (Aches) 02/01/2008 - "The novel compound (+/-)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined mu-opioid receptor agonist and monoamine reuptake inhibitor tramadol."
2.	Neuralgia (Stump Neuralgia) 02/01/2008 - "In the chronic constriction injury model of neuropathic pain, mechanical allodynia and hyperalgesia were both reversed by NS7051 (ED50=6.7 and 4.9mg/kg, s.c.). "
3.	Hyperalgesia 02/01/2008 - "In the chronic constriction injury model of neuropathic pain, mechanical allodynia and hyperalgesia were both reversed by NS7051 (ED50=6.7 and 4.9mg/kg, s.c.). "
4.	Ataxia (Dyssynergia) 02/01/2008 - "No ataxia was observed at antiallodynic doses giving therapeutic indices of 19 and 3 for NS7051 and tramadol. "

Related Drugs and Biologics

1.	mu Opioid Receptors (mu Opioid Receptor)
2.	Tramadol (K315)