F8 monoclonal antibody

a high-affinity human antibody specific to the alternatively spliced oncofetal EDA domain of fibronectin; may serve as useful building block for the development of antibody-based targeted anti-cancer therapeutics; recognizes the human and mouse antigen with comparable affinity

Also Known As:

Networked: 27 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Neri, Dario: 26 articles (01/2021 - 06/2008)
2.	Hemmerle, Teresa: 6 articles (01/2018 - 09/2013)
3.	Villa, Alessandra: 3 articles (01/2021 - 06/2008)
4.	Schmid, Anja Sophie: 3 articles (01/2019 - 08/2015)
5.	Pretto, Francesca: 3 articles (01/2018 - 08/2012)
6.	Casi, Giulio: 3 articles (11/2015 - 07/2014)
7.	Hess, Christian: 3 articles (05/2015 - 02/2014)
8.	Schwager, Kathrin: 3 articles (09/2013 - 12/2010)
9.	Frey, Katharina: 3 articles (09/2013 - 12/2010)
10.	Schliemann, Christoph: 3 articles (09/2013 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "The F8 antibody may serve as useful building block for the development of antibody-based targeted anti-cancer therapeutics. " 07/01/2014 - "Using the F8 antibody, which selectively localizes to the tumor neovasculature, combination treatment led to tumor eradication, in a process dependent on CD8(+) T cells and natural killer cells in the C1498 syngeneic mouse model of acute myelogenous leukemia. " 06/01/2014 - "This study indicates that IL6 can be efficiently delivered to the tumor neo-vasculature by fusion with the F8 antibody. " 05/01/2015 - "This anticancer activity could be potentiated by combination with an immunocytokine based on the F8 antibody and murine IL12, leading to complete and long-lasting tumor eradications. " 06/01/2014 - "F8-IFNγ retained the biologic activity of both the antibody and the cytokine moiety in vitro, but, unlike the parental F8 antibody, it did not preferentially localize to the tumors in vivo. "
2.	Melanoma (Melanoma, Malignant) 09/01/2014 - "We used the K1735M2 immunocompetent syngeneic model of murine melanoma to study the therapeutic activity of F8-IL2, an immunocytokine based on the F8 antibody in diabody format, fused to human IL2. "
3.	Inflammation (Inflammations) 08/01/2015 - "Radiolabeled preparations of the F8 antibody, specific to the EDA domain of fibronectin, were shown to selectively localize to sites of inflammation in mice with colitis, as revealed by autoradiographic analysis. " 10/01/2016 - "In this article, we have analyzed biochemical and pharmaceutical properties of fusion proteins, consisting of the F8 antibody (specific to the EDA domain of fibronectin, a marker of tissue remodeling and of angiogenesis) and of the p40 subunit of interleukin-12, an inhibitor of inflammation. " 11/01/2014 - "The therapeutic activity of F8-IL4, a fusion protein of the F8 antibody (specific to the alternatively-spliced EDA domain of fibronectin) with murine IL4, was investigated in three immunocompetent mouse models of skin inflammation: two induced by the TLR7/8 ligand imiquimod (in Balb/c and C57BL/6) and one mediated by the over-expression of VEGF-A. "
4.	Arthritis (Polyarthritis) 08/19/2014 - "The F8 antibody recognizes the alternatively spliced extra domain A of fibronectin, a marker of angiogenesis, which is strongly overexpressed at sites of arthritis. " 01/01/2018 - "We have previously reported that F8-IL4, a fusion protein consisting of the F8 antibody specific to the alternatively-spliced extra domain A of fibronectin and of murine IL-4, cures mice with established arthritis, when used in combination with dexamethasone (DXM). "
5.	Atherosclerotic Plaque (Atheroma) 02/01/2011 - "Localization of F8 antibody on atherosclerotic plaque structures was further studied in three-color fluorescence microscopy. "

Related Drugs and Biologics

1.	Interleukin-2 (IL2)
2.	Interleukin-6 (Interleukin 6)
3.	Fibronectins (Fibronectin)
4.	Proteins (Proteins, Gene)
5.	Interleukin-12 (IL 12)
6.	Cytokines
7.	Interleukin-4 (Interleukin 4)
8.	Interleukin-10 (Interleukin 10)
9.	Maytansine (Maitansine)
10.	Single-Chain Antibodies

Related Therapies and Procedures

1.	Therapeutics