4- (4- (bis(4- fluorophenyl)methyl)piperazin- 1- ylbut- 2- enyloxy)acetic acid

SUN-1334H is the (E)-isomer,di-HCl salt; an antihistamine; structure in first source

Also Known As:

SUN 1334H; SUN-1334H; SUN1334H

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid: 2
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Acetates: 4994
      - 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid: 2

Experts

1.	Mandhane, Sanjay N: 2 articles (01/2010 - 01/2008)
2.	Rajamannar, Thennati: 2 articles (01/2010 - 01/2008)
3.	Rao, Chitturi Trinadha: 2 articles (01/2010 - 01/2008)
4.	Bagad, Ashish S: 1 article (01/2010)
5.	Bahekar, Prashant C: 1 article (01/2010)
6.	Chidrewar, Gajanan U: 1 article (01/2010)
7.	Mehetre, Sameer V: 1 article (01/2010)
8.	Pawar, Chandrashekhar A: 1 article (01/2010)
9.	Shah, Jigar H: 1 article (01/2010)
10.	Ayer, Upendra B: 1 article (01/2008)

Related Diseases

1.	Rhinitis 01/01/2008 - "In studies of animal models of histamine-mediated disorders, SUN-1334H potently inhibited histamine-induced bronchospasm over 24 hours following oral administration and completely suppressed histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. " 01/01/2008 - "In vivo antihistamine and antiallergy efficacy were assessed following oral administration of SUN-1334H in histamine-induced bronchoconstriction in guinea pigs, skin wheal in beagle dogs and ovalbumin-induced rhinitis (sneezing, vascular permeability and intranasal pressure) in guinea pigs. "
2.	Bronchial Spasm 01/01/2008 - "In studies of animal models of histamine-mediated disorders, SUN-1334H potently inhibited histamine-induced bronchospasm over 24 hours following oral administration and completely suppressed histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. "
3.	Sneezing 01/01/2008 - "In vivo antihistamine and antiallergy efficacy were assessed following oral administration of SUN-1334H in histamine-induced bronchoconstriction in guinea pigs, skin wheal in beagle dogs and ovalbumin-induced rhinitis (sneezing, vascular permeability and intranasal pressure) in guinea pigs. "
4.	Inflammation (Inflammations) 01/01/2010 - "In neurogenic nasal inflammation induced by capsaicin, SUN-1334H and fexofenadine caused better inhibition at lower and middle dose levels than the other antihistamines. "
5.	Hypersensitivity (Allergy) 01/01/2010 - "In skin allergy models, SUN-1334H showed potent reduction of passive and active cutaneous anaphylactic reactions. "

Related Drugs and Biologics

1.	Ovalbumin
2.	Histamine (Histamine Dihydrochloride)
3.	Histamine Antagonists (Antihistamines)
4.	Capsaicin (Zostrix)
5.	fexofenadine (Allegra)

Related Therapies and Procedures

1.	Oral Administration