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PSI-421

second generation analog of PSI-697; P-Selectin inhibitor

Also Known As:

2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid; PSI 421; PSI421

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Hydroxyquinolines: 9
        PSI-421: 1

Experts

1.	Ballard, Nicole E: 1 article (02/2008)
2.	Bedard, Patricia W: 1 article (02/2008)
3.	Hawley, Angela E: 1 article (02/2008)
4.	Kaila, Neelu: 1 article (02/2008)
5.	Londy, Frank J: 1 article (02/2008)
6.	Meier, Thomas R: 1 article (02/2008)
7.	Myers, Daniel D: 1 article (02/2008)
8.	Schaub, Robert G: 1 article (02/2008)
9.	Vlasuk, George P: 1 article (02/2008)
10.	Wakefield, Thomas W: 1 article (02/2008)

Related Diseases

1.	Venous Thrombosis (Deep-Vein Thrombosis) 02/01/2008 - "In this study, a novel oral small-molecule inhibitor of P-selectin, PSI-421, was evaluated in a baboon model of stasis induced deep vein thrombosis (DVT). " 02/01/2008 - "Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation."
2.	Thrombosis (Thrombus) 02/01/2008 - "Experimental groups included i) primates receiving a single oral dose of 1 mg/kg PSI-421 two days prior and continued six days after thrombosis (n = 3); ii) primates receiving a single daily subcutaneous dose of 0.57 mg/kg enoxaparin sodium two days prior and continued six days post thrombosis (n = 3); and iii) primates receiving no treatment (n = 3). " 02/01/2008 - "PSI-421 treated primates had greater percent vein reopening and less vein wall inflammation than the enoxaparin and controls at day 6. Microparticle tissue factor activity (MPTFA) was significantly lower in the animals receiving PSI-421 immediately after thrombosis (T+6 hours day 0) suggesting lower potential for thrombogenesis in these animals. "
3.	Inflammation (Inflammations) 02/01/2008 - "PSI-421 treated primates had greater percent vein reopening and less vein wall inflammation than the enoxaparin and controls at day 6. Microparticle tissue factor activity (MPTFA) was significantly lower in the animals receiving PSI-421 immediately after thrombosis (T+6 hours day 0) suggesting lower potential for thrombogenesis in these animals. "

Related Drugs and Biologics

1.	P-Selectin
2.	Enoxaparin (Lovenox)
3.	Thromboplastin (Tissue Factor)
4.	enoxaparin sodium