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N- (6- Chloropyridin- 3- yl)- 3,4- difluorobenzamide

a KCNQ2/3 channel activator; structure in first source

Also Known As:

ICA 27243; ICA-27243; ICA27243

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Richter, Angelika: 2 articles (01/2016 - 06/2013)
2.	Sander, Svenja E: 2 articles (01/2016 - 06/2013)
3.	Cheng, Jun: 1 article (01/2018)
4.	Fu, Xiaodong: 1 article (01/2018)
5.	Wei, Xiaohong: 1 article (01/2018)
6.	Wen, Jing: 1 article (01/2018)
7.	Yin, Benlan: 1 article (01/2018)
8.	Zhang, Yujiao: 1 article (01/2018)
9.	Diwan, Mustansir: 1 article (01/2016)
10.	Nobrega, José N: 1 article (01/2016)

Related Diseases

1.	Seizures (Absence Seizure) 09/01/2008 - "ICA-27243 was effective against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in both rats (MES, ED(50) = 1.5 mg/kg p.o.; PTZ, ED(50) = 2.2 mg/kg p.o.) and mice (MES, ED(50) = 8.6 mg/kg p.o.; PTZ, ED(50) = 3.9 mg/kg p.o.) in the rat amygdala kindling model of partial seizures (full protection from seizure at 9 mg/kg p.o.) and in the 6-Hz model of psychomotor seizures in mice (active at 10 mg/kg i.p.). "
2.	Dyskinesias (Dyskinesia) 06/17/2013 - "Ten and 15 mg ICA 27243 significantly reduced abnormal involuntary movements (AIM) while no negative impact on the antiparkinsonian effect of L-DOPA was observed. " 06/17/2013 - "The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats."
3.	Pre-Eclampsia (Preeclampsia) 01/01/2018 - "Interestingly, the relaxation ability of ICA-27243 in pre-contracted CPA vessels in women with pre-eclampsia was enhanced. "
4.	Neuroblastoma 03/01/2008 - "In SH-SY5Y human neuroblastoma cells, ICA-27243 produced membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride (XE-991) and linopirdine. "
5.	Epilepsy (Aura) 03/01/2008 - "In conclusion, ICA-27243 represents the first member of a novel chemical class of selective KCNQ2/Q3 activators with anticonvulsant-like activity in experimental models of epilepsy." 03/01/2008 - "ICA-27243 (1-10 microM) was found to reversibly suppress seizure-like activity in an ex vivo hippocampal slice model of epilepsy and demonstrated in vivo anticonvulsant activity (ED(50) = 8.4 mg/kg) in the mouse maximal electroshock epilepsy model. "

Related Drugs and Biologics

1.	Pentylenetetrazole (Metrazol)
2.	Dihydrotachysterol (AT 10)
3.	Levodopa (L Dopa)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	10,10- bis(4- pyridinylmethyl)- 9(10H)- anthracenone
6.	ezogabine (retigabine)
7.	linopirdine