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CCT129202

aurora kinase inhibitor; structure in first source

Also Known As:

2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo(4,5-b)pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - CCT129202: 2
  - Pyridines: 88
    - CCT129202: 2

Experts

1.	Chen, Jun-jiang: 1 article (07/2012)
2.	Chen, Li-kun: 1 article (07/2012)
3.	Chen, Xing-gui: 1 article (07/2012)
4.	Chen, Zhe-sheng: 1 article (07/2012)
5.	Cheng, Chao: 1 article (07/2012)
6.	Fu, Li-wu: 1 article (07/2012)
7.	Liang, Yong-ju: 1 article (07/2012)
8.	Liu, Zhen-guo: 1 article (07/2012)
9.	Singh, Satyakam: 1 article (07/2012)
10.	Talele, Tanaji T: 1 article (07/2012)

Related Diseases

1.	Neoplasms (Cancer) 07/02/2012 - "In conclusion, CCT129202 significantly reversed ABCB1- and ABCG2-mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem-like cells by chemotherapeutic agents. " 07/02/2012 - "Interestingly, CCT129202 also potentiated the sensitivity of cancer stem-like cells to doxorubicin. " 07/02/2012 - "Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202." 12/01/2007 - "CCT129202 causes the accumulation of human tumor cells with >or=4N DNA content, leading to apoptosis. " 07/02/2012 - "Here, we investigated the enhanced effect of CCT129202 on the cytotoxicity of chemotherapeutic drugs in multidrug resistant (MDR) cells with overexpression of ATP-binding cassette (ABC) transporters and cancer stem-like cells. "
2.	Esophageal Neoplasms (Esophageal Cancer) 07/02/2012 - "Importantly, CCT129202 increased the inhibitory effect of vincristine and paclitaxel on ABCB1 overexpressing KBv200 cell xenografts in nude mice and human esophageal cancer tissue overexpressing ABCB1 ex vivo, respectively. "

Related Drugs and Biologics

1.	Aurora Kinases
2.	ATP-Binding Cassette Transporters (ABC Transporters)
3.	Paclitaxel (Taxol)
4.	Vincristine (Oncovin)
5.	Doxorubicin (Adriamycin)
6.	DNA (Deoxyribonucleic Acid)
7.	Adenosine Triphosphate (ATP)