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technetium 99m P1827DS

a 99Tc-labeled leukocyte-avid peptide-glycosaminoglycan complex; used for infection/inflammation imaging

Also Known As:

(99mTc)P1827DS; 99mTc P1827DS

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Glycosaminoglycans: 5640
    - technetium 99m P1827DS: 1
Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organotechnetium Compounds: 1
    - technetium 99m P1827DS: 1

Experts

1.	Baumann, Sabine: 1 article (11/2007)
2.	Boerman, Otto C: 1 article (11/2007)
3.	Corstens, Frans C: 1 article (11/2007)
4.	Cyr, John E: 1 article (11/2007)
5.	Dinkelborg, Ludger M: 1 article (11/2007)
6.	Krause, Sabine: 1 article (11/2007)
7.	Lister-James, John: 1 article (11/2007)
8.	Manchanda, Rajesh: 1 article (11/2007)
9.	Rennen, Huub J: 1 article (11/2007)

Related Diseases

1.	Infections 11/01/2007 - "The accumulation of [99mTc]P1827/DS at the infection site strongly depends on the P1827/DS ratio and was optimal at a molar ratio of 10:1. [99mTc]P1827DS shows improved biodistribution over [99mTc]P483H with similar uptake at the infection site. " 11/01/2007 - "However, the infection uptake and biodistribution of [99mTc]P1827DS is not superior to that of [99mTc]HYNIC-IL-8 in this animal model." 11/01/2007 - "In this study, the potential of [99mTc]P1827DS for infection imaging was assessed in comparison with [99mTc]P483H and the well-described imaging agent [99mTc] hydrazinonicotinamide (HYNIC)-interleukin 8 (IL-8). " 11/01/2007 - "The technetium 99 m (99mTc)-radiolabeled, leukocyte-avid peptide-glycoseaminoglycan complex, [99mTc]P1827DS, has been synthesized as an improved infection/inflammation imaging agent to [99mTc]P483H (LeukoTect, Diatide). "
2.	Inflammation (Inflammations) 11/01/2007 - "[99mTc]P1827DS is a potential new inflammation imaging agent, which clearly visualized the abscess in the rabbit E. " 11/01/2007 - "The technetium 99 m (99mTc)-radiolabeled, leukocyte-avid peptide-glycoseaminoglycan complex, [99mTc]P1827DS, has been synthesized as an improved infection/inflammation imaging agent to [99mTc]P483H (LeukoTect, Diatide). "
3.	Escherichia coli Infections 11/01/2007 - "A rabbit Escherichia coli infection model was used to perform the biodistribution and imaging studies with [99mTc]P1827DS, [99mTc]P483H and [99mTc]HYNIC-IL-8. [99mTc]P1827DS binds to leukocytes but not to erythrocytes. "
4.	Abscess 11/01/2007 - "Abscess uptake of [99mTc]HYNIC-IL-8 was approximately three times higher than that of [99mTc]P1827DS. " 11/01/2007 - "[99mTc]P1827DS is a potential new inflammation imaging agent, which clearly visualized the abscess in the rabbit E. "

Related Drugs and Biologics

1.	Technetium (Technetium 99m)
2.	Peptides (Polypeptides)
3.	Interleukin-8 (Interleukin 8)