HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

21- (2- N,N- diethylaminoethyl)oxy- 7- methyl- 19- norpregna- 1,3,5(10)- triene- 3- O- sulfamate

an estrone sulfatase inhibitor and hormonal antineoplastic agent; structure in first source

Also Known As:

21-DOMNTS; NSC 732011; NSC-732011; NSC732011; SR 16157; SR-16157; SR16157

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Norsteroids: 16
      - Norpregnanes: 2
        Norpregnatrienes
        21-(2-N,N-diethylaminoethyl)oxy-7-methyl-19-norpregna-1,3,5(10)-triene-3-O-sulfamate: 4

Experts

1.	Zaveri, Nurulain: 2 articles (06/2011 - 11/2007)
2.	Catz, Paul: 1 article (06/2011)
3.	Green, Carol: 1 article (06/2011)
4.	LeValley, Sue: 1 article (06/2011)
5.	Mirsalis, Jon: 1 article (06/2011)
6.	Rausch, Linda: 1 article (06/2011)
7.	Schweikart, Karen: 1 article (06/2011)
8.	Steinmetz, Karen: 1 article (06/2011)
9.	Tomaszewski, Joseph: 1 article (06/2011)
10.	Lykkesfeldt, Anne E: 1 article (12/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/2011 - "SR16157 is a promising agent for the endocrine therapy of breast cancer. " 12/01/2007 - "In this study, we tested the potential of SR 16157 and SR 16137 on STS activity, cell growth and ERalpha function in MCF-7 breast cancer cells. " 11/30/2007 - "SR16157 (21-(2-N,N-diethylaminoethyl)oxy-7alpha-methyl-19-norpregna-1,3,5(10)-triene-3-O-sulfamate) is a novel, dual-acting estrone sulfatase inhibitor currently in preclinical development for use in breast cancer therapy. " 12/01/2007 - "A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer."
2.	Chromosome Aberrations (Chromosome Abnormalities) 05/18/2007 - "In the chromosomal aberration assay, of the 8 compounds that were tested, 4'-bromoflavone elicited a positive response in the absence of S9 only, while SR16157 was positive in the presence of S9. "

Related Drugs and Biologics

1.	Estrogen Receptor alpha
2.	Steryl-Sulfatase (Steroid Sulfatase)
3.	Estrogen Receptor Modulators (Antiestrogen)
4.	estrone sulfatase

Related Therapies and Procedures

1.	Therapeutics