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5- amino- 2- ((1- n- propyl- 1H- imidazol- 4- yl)methyl)pentanoic acid

a TAFIa inhibitor; structure in first source

Also Known As:

5-amino-PIMPA; UK 396,082; UK 396082; UK-396,082; UK-396082; UK396,082; UK396082

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - 5-amino-2-((1-n-propyl-1H-imidazol-4-yl)methyl)pentanoic acid: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 5-amino-2-((1-n-propyl-1H-imidazol-4-yl)methyl)pentanoic acid: 3

Experts

1.	Ariens, Robert: 1 article (01/2017)
2.	Bailey, Marc: 1 article (01/2017)
3.	Bridge, Katherine: 1 article (01/2017)
4.	Butlin, Roger: 1 article (01/2017)
5.	Foster, Richard: 1 article (01/2017)
6.	Gils, Ann: 1 article (01/2017)
7.	Macrae, Fraser: 1 article (01/2017)
8.	Revill, Charlotte: 1 article (01/2017)
9.	Scott, D Julian: 1 article (01/2017)
10.	Wheatcroft, Stephen: 1 article (01/2017)

Related Diseases

1.	Rupture 01/01/2017 - "Inhibition of TAFI in the Angiotensin II model resulted in a decrease in the mortality associated with AAA rupture (from 40.0% to 16.6% with MA-TCK26D6 (log-rank Mantel Cox test p = 0.16), and 8.3% with UK-396082 (log-rank Mantel Cox test p = 0.05)). "
2.	Fibrosis (Cirrhosis) 08/01/2015 - "We made similar observations in rats after subtotal nephrectomy and tested whether pharmacologic inhibition of thrombin-activated fibrinolysis inhibitor with UK-396082 could reduce renal fibrosis and improve renal function. "
3.	Cicatrix (Scar) 06/24/2013 - "The results support the hypothesis that UK-396082 is able to reduce TAFI activity, normalising plasmin activity and preventing excess ECM accumulation suggesting that TAFI inhibition may have potential as an anti-scarring strategy in CKD. "

Related Drugs and Biologics

1.	Thrombin
2.	Fibrinolysin
3.	Angiotensin II

Related Therapies and Procedures

1.	Nephrectomy