Bay w 9798

a dihydropyridine structurally related to nifedipine with no calcium channel-blocking properties, inhibits tumour necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells by suppressing reactive oxygen species generation; structure in first source

Also Known As:

1,2,6-trimethyl-4-(4-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - Bay w 9798: 2

Experts

1.	Inoue, H: 1 article (11/2007)
2.	Matsui, T: 1 article (11/2007)
3.	Nakamura, K: 1 article (11/2007)
4.	Yamagishi, S: 1 article (11/2007)
5.	Cattaruzza, M: 1 article (03/2000)
6.	Hecker, M: 1 article (03/2000)
7.	Wachter, R: 1 article (03/2000)
8.	Wagner, A H: 1 article (03/2000)

Related Diseases

1.	Atherosclerosis 11/01/2007 - "The aim of this study was to determine in TNF-alpha-exposed human umbilical vein endothelial cells (HUVECs) whether and how Bay w 9798, a dihydropyridine structurally related to nifedipine with no calcium antagonistic properties, may suppress VCAM-1 expression, a key molecule which mediates the adhesion of monocytes to vasculature in the early stages of atherosclerosis. "
2.	Necrosis 11/01/2007 - "Bay w 9798, a dihydropyridine structurally related to nifedipine with no calcium channel-blocking properties, inhibits tumour necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells by suppressing reactive oxygen species generation." 03/01/2000 - "2. Both, nifedipine and Bay w 9798, in concentrations ranging from 0.01 to 1 microM, augmented the interleukin-1beta/tumour necrosis factor-alpha (IL-1beta/TNF-alpha)-induced expression of the inducible isoform of nitric oxide synthase (iNOS) in rat aortic cultured smooth muscle cells (raSMC) 2 - 3 fold, as judged by RT - PCR and Western blot analyses. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Nifedipine (Adalat)
3.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
4.	Calcium
5.	1,4-dihydropyridine (dihydropyridine)
6.	Interleukin-1beta (Interleukin 1 beta)
7.	Protein Isoforms (Isoforms)
8.	Nitric Oxide Synthase (NO Synthase)
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Calcium Channels (Calcium Channel)